Stock material or miscellaneous articles – Coated or structually defined flake – particle – cell – strand,... – Particulate matter
Patent
1989-06-01
1991-01-22
Lovering, Richard D.
Stock material or miscellaneous articles
Coated or structually defined flake, particle, cell, strand,...
Particulate matter
424456, 424491, 424492, 42840224, A61K 948, A61K 950, B01J 1302
Patent
active
049870319
DESCRIPTION:
BRIEF SUMMARY
DESCRIPTION
1. Technical Field
This invention relates to gelatin composite for the use of capsules to fill medicine and the like, coating agents or binding agents of tablets, casing materials and so on.
2. Background Art
Some medicines, for example, are cased in capsules to prepare capsule medicines which are used with a purpose of easy taking or sure absorption at the digestive organ destined. A capsule for such use is required to have a shape-retaining ability which can retain the shape under various conditions, and to show disintegration which does not change with the passage of time.
The change of disintegration with the passage of time is said to be caused by that the gelatin, a main component of the capsule, reacts by themselves or with a substance enclosed in the capsule, and becomes insoluble as the time passes.
Japanese Patent Gazette (Kokai) No. 58-62120 discloses a soft capsule, which can prevent that kind of insolubilization of gelatin with the passage of time. The soft capsule is a gelatin composite comprising addition of polypeptide of 0.5-10% by weight of the gelatin. The soft capsule was devised to prevent the insolubilization by allowing the added polypeptide to react with an enclosed substance before gelatin reacts.
However, it was found by experiments of the present inventors that, in a case of that the substance enclosed is highly reactive, the amount of polypeptide consumption with the reaction seriously increase resulting in an unsufficient prevention of the insolubilization with the use of amount in the above range. Then, if polypeptide is added over the range to solve the unsufficient prevention, it turns out to lead to degradation of the shape-retaining ability of the gelatin composite or the products comprising it.
Considering these situations, the present invention was undertaken to provide gelatin composite which can prevent the insolubilization of gelatin due to the passage of time without any degradation of the shape-retaining ability of gelatin composite.
DISCLOSURE OF INVENTION
The invention provides a gelatin composite characterized by comprising gelatin and polypeptide as an essential component, wherein the polypeptide is in the range of 15-70% by weight, referring to the total weight of the polypeptide and gelatin, and the gelatin has a gelly strength of 250 bloom or greater.
Below is the detailed description of the invention.
Gelatin composite of this invention comprises gelatin and polypeptide as an essential component. Besides the two, the gelatin composite may be added with one or more of plasticizer, thickener, agent for coloring, etc. Some examples of the plasticizer are glycerin and sorbitol, and they may be employed solely or in combination. Some examples of thickener are gum arabic and alginic acid, and they may be employed solely or in combination. Some examples of agents for coloring are various food colors, and they may be employed solely or in combination.
Gelatin used in the invention is required to have a gelly strength of 250 bloom or greater. That is because, if the strength is below than 250 bloom, the shape-retaining ability of gelatin composite or products comprising it degrades even though the amount of the added polypeptide is relatively small. Herein the gelly strength was tested in accordance with JIS K 6503 (1977 edition).
Gelatin may be produced under mild conditions preventing any degradation factor of its gelly strength in order to keep a high gelly strength. However, it may be prepared in other methods, or obtained from the market where gelatins having a gelly strength of 250 bloom or greater are available.
The kind of polypeptide for the invention is not specialized. However, the polypeptide ratio should be here in the range of 15-70% by weight, referring to the total weight of the polypeptide and gelatin. If polypeptide is added over the range, gelatin composite or products comprising it may have a very low shape-retaining ability and will be unfavorable for practical use. If polypeptide is added under the range, the prevention effect on
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patent: 3092553 (1963-06-01), Fisher, Jr. et al.
patent: 3436452 (1969-04-01), Maierson
patent: 3576758 (1971-04-01), Emrick
patent: 3851051 (1974-11-01), Miskel et al.
patent: 4609403 (1986-09-01), Wittwer et al.
Hashimoto Tatsuo
Ito Noriichi
Omata Kazuki
Takahashi Masato
Tatematsu Shinzo
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