Capsular polysaccharide immunomodulator

Details Capsular polysaccharide immunomodulator Capsular polysaccharide immunomodulator

1995-07-14

1997-12-23

Kight, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 55, 514 56, 514 61, 424831, A61K 31715, A61K 31725, A61K 3173, A61K 31735

Patent

active

057007870

ABSTRACT:
Methods and products for protecting against abscess formation associated with surgery, trauma or diseases that predispose the host to abscess formation are provided. Methods for forming immunomodulators and pharmaceutical compositions relating thereto also are provided. The products useful in the invention are polysaccharides including a repeat unit having a positively charged free amino group and a negatively charged group. The preferred polysaccharide is B. fragilis capsular polysaccharide A.

REFERENCES:
patent: 5576002 (1996-11-01), Jennings et al.
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Tzianabos, A.O. et al., Strructure-function relationships for polysaccharide-induced intraabdominal abscesses,, Infect Immun 62:3590-3593 (1994).
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Baumann, H. et al., Structural elucidation of two capsular polysaccharides from one strain of Bacteroides fragilis using high-resolution NMR spectroscopy,, Biochemistry 31(16):4081-4089 (1992).
Tzianabos, A.O. et al., The capsular polysaccharide of Bacteroides fragilis comprises two ionically linked polysaccharides., J. Biol. Chem. 267(25):18230-18235 (1992).
Tzianabos, A.O. et al., Structural characteristics of polysaccharides that induce protection against intra-abdominal abscess formation., Infect. Immun. 62(11):4881-4886 (1994).

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