Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1988-02-19
1990-06-05
Rollins, John W.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
514811, A61K 3578
Patent
active
049312774
DESCRIPTION:
BRIEF SUMMARY
FIELD OF THE INVENTION
This invention relates to new medicaments that can be used in human therapy as well as processes for obtaining them and their physicochemical and therapeutic characteristics.
These products are intended for the prevention and treatment of alcoholic toxicomania because of their pharmacological activities able to induce in most treated patients a loss of habit and even a disgust for alcoholic beverages.
BACKGROUND OF THE INVENTION
In our day alcoholism remains a medical and major social scourge. For example, in France in 1984, the annual average consumption of pure alcohol per inhabitant was 13.5 liters. Specialists estimate that for France the number of persons intoxicated by alcohol is five million, of whom two million are alcoholic and three million are excessive drinkers.
The medical, social and economic repercussions of alcoholic toxicomania was figured at an overall cost of about 75 billion francs for the French community for 1982: costs of sickness linked to alcoholism, work accidents, traffic accidents, premature deaths, loss of days of work, etc. . .
At present, actual alcoholic detoxication treatments used proceed from the use of the Antabuse effect of disulfiram and the use of the Dr. Champeau method (daily injection of 15% hypertonic solution of magnesium sulfate), both of which methods which aim at inducing an intolerance or a lack of habit for alcoholic beverages.
These treatments are difficult to use: there is risk of intoxication and secondary accidents due to disulfiram, restricting treatment for magnesium sulfate injections and risks of intolerance accidents. Despite these drawbacks, these treatments on an average make it possible to obtain about 50% good quality withdrawals in patients treated.
Besides their medical drawbacks, these antialcoholic treatments impose very heavy and very costly material, physical, psychological and institutional constraints on the community and public health economy. Further, they cause the alcoholic patient to be taken over totally: his detoxication rests on a principle of medical authority who tends to replace the patient's will and on a principle of sanctions linked to displeasures induced by ingestion of alcohol.
SUMMARY OF THE INVENTION
The inventors discovered that it was possible successfully to use, in antialcoholic cures, new medicaments consisting of extracts used either alone or in association and obtained from two vegetable species: the fruit of the pimento (Capsicum) and the wood and/or bark of the poplar (Populus).
The products according to the invention represent a notable advance relative to the preceding substances used in antialcoholic cures by the following characteristics:
They are products obtained by extraction and purification from vegetable substances. They are completely free of toxicity. Doses fifty times greater than therapeutic doses used in humans were administered to laboratory animals (mice, guinea pigs) without inducing notable toxic manifestations. Moreover, the vegetables from which these extracts are taken belong to the pharmacopeia and are known for their nontoxicity. On the other hand, their antialcoholic property is not known so far.
They are products that can be administered orally which do not require hospitalizing the patient. Further, these treatments can be used, without the patient's knowledge, by his family by adding the medicament to his usual drinks and foods. One daily dose is generally sufficient.
These treatments do not impose sudden alcoholic withdrawal; the patient to be detoxicated can have access to his usual alcoholic beverages whose consumption he gradually reduces as the therapeutic successes of the medicaments, which is the object of the invention, are felt.
These treatments give results qualitatively superior to those obtained by the present standard treatments cited above. The therapeutic successes marked by a good quality alcoholic withdrawal without relapse, can be figured at about 65 to 70% of cases treated.
Consequently, these treatments mark a notable advance both by
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Lust, the Herb Book, pp. 147-148, 311-313 (1974).
Bonneau Marc
Fontaine Michel
Catchpole Wendy
Rollins John W.
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