Capsacinoid compounds as proliferation inhibitors

Details Capsacinoid compounds as proliferation inhibitors Capsacinoid compounds as proliferation inhibitors

1994-05-24

1996-10-29

Nutter, Nathan M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

A01N 3734, A61K 31275

Patent

active

055696732

ABSTRACT:
N-Acylated catecholmethylamines are used to inhibit cancer cell proliferation. Specifically, capsaicin is found to inhibit growth at low concentration, but not normal cells.

REFERENCES:
patent: 5001115 (1991-03-01), Sloan
Bruno et al., "Stimulation of NADH Oxidase Activity from Rat Liver Plasma Membranes by Growth Factors and Hormones is Decreased or Absent with Hepatoma Plasma Membranes", J. of Biochem. 284:625-628 (1992).
Morre et al. "NADH Oxidase of Liver Plasma Membrane Stimulated by Diferric Transferrin and Neoplastic Transformation Induced by the Carcinogen 2-Acetylaminofluorene", Biochimica et Biophysica Acta 1057:140-146 (1991).
Morre and Crane, "Oxidoreduction at the Plasma Membrane: Relation to Growth and Transport" vol. I; Animals Eds. Crane, Morre and Low (CRC Press, Boca Raton, FL), pp. 67-84 (1990).
Sun et al., "Requirement for Coenzyme Q in Plasma Membrane Electron Transport", Prod. Natl. Acad. Sci. USA 89:11126-11130 (1992).

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