Capreomycin derivatives and their use as antibacterials

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C530S317000

Reexamination Certificate

active

11261717

ABSTRACT:
The present subject matter relates to phenylurea capreomycin derivatives, and to metabolites and pharmaceutically acceptable salts and solvates thereof. The compounds of the present subject matter are useful as antibacterial agents for treating bacterial infections and for treating disorders caused by bacterial infections. The present subject matter also relates to pharmaceutical compositions containing such compounds and to methods of treating bacterial infections by administering such compounds. The present subject matter also relates to methods of preparing such compounds.

REFERENCES:
Dirlam, et al., Bioorganic and Medicinal Chemistry Letters, 1997, 7(9), 1139-1144.
R.G. Linde II, “Cyclic Homopentapeptides 3. Synthetic Modifications to the Capreomycins and Tuberactinomycins: Compounds with Activity Against Methicillin-Resistant Staphylococcus Aureus And Vancomycin-Resistant Enterococci” Bioorganic & Medical Chemistry Letters, vol. 7, Oxford, GB, 1997.
J.P. Dirlam, “Cyclic Homopentapeptides 1. Analogs of Tuberactinomycins and Capreomycin with Activity Against Vancomycin-Resistant Enterococci and Pasteurella”, Bioorganic & Medical Chemistry Letters, vol. 7, Oxford, GB, 1997.
Mu Wang, Steven J. Gould, “Biosynthesis of Capreomycin. 2. Incorporation of L-Serine, L-Alanine, and L-2,3-Diaminopropionic Acid” Journal of Organic Chemistry, vol. 58, 1993, pp. 5176-5180.
Steven J. Gould, “Biosynthesis of Capreomycin. 1. Incorporation of Arginine” Journal of Organic Chemistry, vol. 57, 1992, pp. 5214-5217.
International Preliminary Report On Patentability, date of mailing: May 18, 2007, (10 pages).

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