CAPL-specific oligonucleotides and methods of inhibiting metasta

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

536 243, 536 2431, 536 2433, 435 6, 4351721, 4351723, 4353201, 435375, C07H 2100, C12N 510, C12Q 168

Patent

active

058773088

ABSTRACT:
Disclosed are synthetic oligonucleotides having a nucleotide sequence complementary to CAPL nucleic acid. Also disclosed are methods of inhibiting the expression of CAPL gene and methods of inhibiting metastatic cancer using CAPL-specific oligonucleotides.

REFERENCES:
E. Uhlmann et al. Chem. Reviews 90(4) 543-584 ('90).
P. Westermann et al. Biomed. Biochim Aero 48(1) 85-93 ('89).
W. James Antiviral Chem & Chemotherapy 2(4) 191-214 ('91).
R. Stoll et al. Pharmaceut. Res. 12(4) 465-83 ('95).
Cairns (1981) Nature 289:353-57.
Nicolson (1982) Biochim. Biophys. Acta 695:113-176.
Nicolson (1984) Cancer Metast. Rev. 3:24-42.
Klein et al. (1985) Nature 315:190-195.
Nicolson (1987) Cancer Res. 47:1473-1487.
Berger et al. (1988) Cancer Res. 48:1238-1243.
Ebralidze et al. (1989) Genes Dev. 3:1086-1093.
Kjonniksen et al. (1990) J. Nat. Cancer Inst. 82(5) Mar.
Monocrief (1990) J. Mol. Evol. 30:522-562.
Heizmann et al. (1991) TIBS 16:98-103.
Hilt et al. in Novel Calcuim-binding Proteins (Heizmann, C.W., ed.) Springer-Verlag, Berlin, 1991, pp. 65-103.
Engelkamp et al. (1992) Biochem. 31:10258-10264.
Engebraten in Biology and Experimental Therapy of Invasive glioma cells in tissue culture, The Gade Institute, Department of Pathology, University of Berger, Norway (1992).
Lee et al. (1992) Proc. Natl. Acad. Sci. (USA) 89:2504-2508.
Davies et al. (1993) Oncogene 8:999-1008.
Engelkamp et al. (1993) Proc. Natl. Acad. Sci. (USA) 90:6547-6551.
Stein et al. (1993) Science 261:1004-1012.
Tulchinsky et al. (1993) Oncogene 8:79-86.
Kriajevska et al. (1994) J. Biol. Chem. 269:19679-19682.
Wagner (1994) Nature 372:333-335.
Kligman et al. (1988) TIBS 13:437-442.
Engelkamp et al. (1993) Proc. Natl. Acad. Sci. USA 90:6547-6551.
Agrawal (1992) Trends in Biotech. 10:152.
Maelandsmo et al. (1995) Cancer Research 55:2884.
James (1991) Antiviral Chemistry & Chemotherapy 2:191-214.
Milligan et al. (1993) Journal of Medicinal Chemistry 36:1923-1937.
Rojanasakul (1996) Advanced Drug Delivery Reviews 18:115-131.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

CAPL-specific oligonucleotides and methods of inhibiting metasta does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with CAPL-specific oligonucleotides and methods of inhibiting metasta, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and CAPL-specific oligonucleotides and methods of inhibiting metasta will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-424112

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.