CAPL-specific oligonucleotides and method of inhibiting metastat

Details CAPL-specific oligonucleotides and method of inhibiting metastat CAPL-specific oligonucleotides and method of inhibiting metastat

1996-02-16

1998-08-04

Rories, Charles C. P.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

536 231, 536 243, 536 2431, 536 2433, 536 245, 514 44, 435 6, C12N 510, C07H 2100, A61K 3170, A61K 4800

Patent

active

057892482

ABSTRACT:
Disclosed are synthetic oligonucleotides having a nucleotide sequence complementary to CAPL nucleic acid. Also disclosed are methods of inhibiting the expression of CAPL gene and methods of inhibiting metastatic cancer using CAPL-specific oligonucleotides.

REFERENCES:
E. Uhlmann et al. Chem. Reviews 90(4):543-84 ('90).
P. Westermann et al. Biomed. Biochim. Acta 48(1):85-93 ('89).
W. James Antiviral Chem & Chemotherapy 2(4)191-214 ('93).
J. Milligan et al. J. Med. Chem. 36(14):1923-37 ('93).
B. Tseng et al. Cancer Gene Therapy 1(1):65-71 ('94).
R. Stull et al. Pharmaceut. Res. 2(4):465-83 ('95).
Y. Rojanasakul Adv. Drug Del. Rev. 18:115-31 ('96).
Cairns (1981) Nature 289:353-57.
Nicolson (1982) Biochim. Biophys. Acta 695:113-176.
Nicolson (1984) Cancer Metast. Rev. 3:24-42.
Klein et al. (1985) Nature 315:190-195.
Nicolson (1987) Cancer Res. 47:1473-1487.
Berger et al. (1988) Cancer Res. 48:1238-1243.
Ebralidze et al. (1989) Genes Dev. 3:1086-1093.
Kjonniksen et al. (1990) J. Nat. Cancer Inst. 83(5) Mar.
Moncrief (1990) J. Mol. Evol. 30:522-562.
Heizmann et al. (1991) TIBS 16:98-103.
Hilt et al. in Novel Calcium-binding Proteins (Heizmann, C.W., ed.) Springer-Verlag, Berlin, 1991, pp. 65-103.
Engelkamp et al. (1992) Biochem. 31:10258-10264.
Engebraten in Biology and Experimental Therapy of Invasive glioma cells in tissue culture, The Gade Institute, Department of Pathology, University of Berger, Norway (1992).
Lee et al. (1992) Proc. Natl. Acad. Sci. (USA) 89:2504-2508.
Davies et al. (1993) Oncogene 8:999-1008.
Engelkamp et al. (1993) Proc. Natl. Acad. Sci. (USA) 90:6547-6551.
Stein et al. (1993) Science 261:1004-1012.
Tulchinsky et al. (1993) Oncogene 8:79-86.
Kriajevska et al. (1994) J. Biol. Chem. 269:19679-19682.
Wagner (1994) Nature 372:333-335.
Kligman et al. (1988) TIBS 13:437-442.
Engelkamp et al. (1993) Proc. Natl. Acad. Sci. USA 90:6547-6551.
Stein et al. (1993) Science 261:1004-1012.
Agrawal (1992) Trends in Biotech. 10:152.
Maelandsmo et al. (1995) Cancer Research 55:2884.

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