Capillary tube with reduced protein interactions and controllabl

Details Capillary tube with reduced protein interactions and controllabl Capillary tube with reduced protein interactions and controllabl

1988-08-19

1990-06-05

Seidleck, James

Stock material or miscellaneous articles

Hollow or container type article

Polymer or resin containing

204299R, 2041801, 2041828, 428426, 428 347, B01D 6142

Patent

active

049313282

ABSTRACT:
A method for treating capillary walls exposable to protein solutes is provided that reduces interactions of the protein solutes with the wall and that permits control of electroosmotic flow within the capillaries by selection of solution pH. Thus, a capillary tube has an interfacial layer covalently bonded to the inner wall of the tube. This interfacial layer is effective to reduce interactions between the inner wall and protein solutes and preferably includes a hydratable amphoteric phase. The amphoteric phase is a reaction product of a protein, peptide or an ampholyte and an oxygen or nitrogen nucleophile. Electroosmotic flow magnitude and/or flow direction may be controlled when capillaries of the invention are used for electrophoretic separations.

REFERENCES:
patent: 4680201 (1987-07-01), Hjerten
patent: 4690749 (1987-09-01), Van Alstine et al.
Jorgenson, LuKacs, Capillary Zone Electrophoresis, Science 222 pp. 266-272 (1983).

Affiliated with

Also associated with

Rating

Capillary tube with reduced protein interactions and controllabl does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Capillary tube with reduced protein interactions and controllabl, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Capillary tube with reduced protein interactions and controllabl will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-490987