Chemistry: analytical and immunological testing – Hemoglobin – myoglobin – or occult blood
Patent
1989-01-31
1991-10-29
Johnston, Jill
Chemistry: analytical and immunological testing
Hemoglobin, myoglobin, or occult blood
356 41, 356339, 356341, 422 73, 422 8205, 436 68, 436 67, G01N 2151
Patent
active
050616323
ABSTRACT:
An oximeter that measures both the total hemoglobin concentration in whole, undiluted blood and the percentage of the hemoglobin saturated with oxygen. The oximeter uses red and infrared light-emitting diodes to illuminate a capillary tube filled with a sample of whole, undiluted blood. Light scattered by the blood travels a short distance down the length of the capillary tube and reaches a photodetector, the output of which is amplified, digitized, and fed to a microprocessor. The microprocessor computes the total hemoglobin concentration as a nonlinear monotonic function of the infrared light intensity. Oxyhemoglobin saturation is computed from the ratio of the logarithms of the intensities of red and infrared light. The invention provides a measurement of oxygen saturation without calibration shifts present in other oximeters due to fluctuations in total hemoglobin concentration. In addition, the present invention is accurate over a wide range of oxygen saturation, and the blood samples are not diluted or hemolyzed and can thus be preserved for further analysis.
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Shepherd A. P.
Steinke John M.
Board of Regents , The University of Texas System
Johnston Jill
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