Capillary tube hemoglobinometer and oximeter

Chemistry: analytical and immunological testing – Hemoglobin – myoglobin – or occult blood

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

356 41, 356339, 356341, 422 73, 422 8205, 436 68, 436 67, G01N 2151

Patent

active

050616323

ABSTRACT:
An oximeter that measures both the total hemoglobin concentration in whole, undiluted blood and the percentage of the hemoglobin saturated with oxygen. The oximeter uses red and infrared light-emitting diodes to illuminate a capillary tube filled with a sample of whole, undiluted blood. Light scattered by the blood travels a short distance down the length of the capillary tube and reaches a photodetector, the output of which is amplified, digitized, and fed to a microprocessor. The microprocessor computes the total hemoglobin concentration as a nonlinear monotonic function of the infrared light intensity. Oxyhemoglobin saturation is computed from the ratio of the logarithms of the intensities of red and infrared light. The invention provides a measurement of oxygen saturation without calibration shifts present in other oximeters due to fluctuations in total hemoglobin concentration. In addition, the present invention is accurate over a wide range of oxygen saturation, and the blood samples are not diluted or hemolyzed and can thus be preserved for further analysis.

REFERENCES:
patent: 30007 (1879-05-01), Steuer et al.
patent: 2878715 (1959-03-01), Rhees
patent: 3296922 (1967-01-01), Goldberg
patent: 3527542 (1966-06-01), Penhasi et al.
patent: 3638640 (1972-02-01), Shaw
patent: 3692410 (1972-09-01), Jurany et al.
patent: 3764267 (1973-10-01), Farr
patent: 3799672 (1974-03-01), Vurek
patent: 3972614 (1976-08-01), Johansen et al.
patent: 3994585 (1976-11-01), Frey
patent: 4003662 (1977-01-01), Retzer et al.
patent: 4013417 (1977-03-01), Raffaele
patent: 4057394 (1977-11-01), Genshaw
patent: 4134678 (1979-01-01), Brown et al.
patent: 4240749 (1980-12-01), Retzer
patent: 4243883 (1981-01-01), Schwarzmann
patent: 4301412 (1981-11-01), Hill et al.
patent: 4303887 (1981-12-01), Hill et al.
patent: 4308029 (1981-12-01), Siggaard-Andersen
patent: 4324556 (1982-04-01), Robertson et al.
patent: 4357105 (1982-11-01), Loretz
patent: 4444498 (1984-04-01), Heinemann
patent: 4453266 (1984-06-01), Bacus
patent: 4502786 (1985-03-01), Golias et al.
patent: 4565448 (1986-01-01), Abbott et al.
patent: 4605305 (1986-08-01), Lenoir et al.
patent: 4651741 (1987-05-01), Passafaro
patent: 4700708 (1987-10-01), New, Jr. et al.
J. W. Kiel and A. P. Shepherd, "A Microcomputer Oximeter for Whole Blood", Amer. J. Physiol., vol. 244, pp. H722-H725, 1983.
J. M. Steinke and A. P. Shepherd, "Role of Light Scattering in Whole Blood Oximetry", IEEE Transactions on Biomedical Engineering, vol. BME-33, No. 3, Mar. 1986.
N. M. Anderson and P. Sekelj, "Light-Absorbing and Scattering Properties of Non-Haemolysed Blood", Phys. Med. Biol., vol. 12, pp. 173-184, 1967.
K. Kramer, J. O. Elam, G. A. Saxton and W. N. Elam, Jr., "Influence of Oxygen Saturation, Erythrocyte Concentration and Optical Depth Upon the Red and Near-Infrared Light Transmittance of Whole Blood", Amer. J. Physiol., vol. 165, pp. 229-246, Apr. 1951.
F. J. Janssen, "A Study of the Absorption and Scattering Factors of Light in Whole Blood", Med. Biol. Eng., vol. 10, pp. 231-240, 1972.
D. L. Drabkin, "The Crystallographic and Optical Properties of the Hemoglobin of Man in Comparison with Those of Other Species", J. Biol. Chem., vol. 164, pp. 703-723, 1946.
Setsuo Takatani, Hiroyuki Noda, Hisateru Takano and Tetsuzo Akutsu, "A Miniature Hybrid Reflection Type Optical Sensor for Measurement of Hemoglobin Content and Oxygen Saturation of Whole Blood", IEEE Transactions on Biomedical Engineering, vol. 34, No. 3, Mar. 1988.
M. Singh and K. P. Joseph, "Optical Method for Haematocrit determination", Med. & Biol. Eng. & Comput., vol. 20, pp. 527-528.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Capillary tube hemoglobinometer and oximeter does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Capillary tube hemoglobinometer and oximeter, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Capillary tube hemoglobinometer and oximeter will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1400218

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.