Capillary immunoassay and device therefor comprising mobilizable

Details Capillary immunoassay and device therefor comprising mobilizable Capillary immunoassay and device therefor comprising mobilizable

1993-07-15

1997-04-22

Spiegel, Carol A.

Chemistry: analytical and immunological testing

Involving diffusion or migration of antigen or antibody

422 56, 422 58, 422 60, 435 71, 435962, 435970, 435971, 435973, 436510, 436518, 436541, 436805, 436810, 436817, 436818, G01N 33558

Patent

active

056228716

ABSTRACT:
An analytical test device useful for example in pregnancy testing, includes a hollow casing (500) constructed of moisture-impervious solid material, such as plastics materials, containing a dry porous carrier (510) which communicates indirectly with the exterior of the casing via a bibulous sample receiving member (506) which protrudes from the casing such that a liquid test sample can be applied to the receiving member and permeate therefrom to the porous carrier, the carrier containing in a first zone a labelled specific binding reagent is freely mobile within the porous carrier when in the moist state, and in a second zone spatially distinct from the first zone unlabelled specific binding reagent for the same analyte which unlabelled reagent is permanently immobilised on the carrier material and is therefore not mobile in the moist state, the two zones being arranged such that liquid sample applied to the porous carrier can permeate via the first zone into the second zone, and the device incorporating an aperture (508) in the casing, enabling the extent (if any) to which the labelled reagent becomes bound in the second zone to be observed. Preferably the device includes a removable cap for the protruding bibulous member.

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