Chemistry: electrical and wave energy – Processes and products – Electrostatic field or electrical discharge
Patent
1992-04-22
1993-08-03
Valentine, Donald R.
Chemistry: electrical and wave energy
Processes and products
Electrostatic field or electrical discharge
204299R, G01N 2726, G01N 27447
Patent
active
052325652
ABSTRACT:
In the capillary electrophoretic system, the components of a sample to be separated and detected are labelled by a radioactive material which emits gamma rays or beta particles with energy high enough to penetrate the electrolyte and the capillary tube. A semiconductor detector outside the tube and placed adjacent to the tube detects the gamma rays or beta particles in order to detect the presence of the components of the sample. A weaker radio-label may also be used in conjunction with scintillating material which is introduced together with the sample into the tube or through a different tube. Alternatively, the scintillating material may be placed inside the tube or made a part of the tube. The scintillating material emits light in response to radiation from the radio labels on the components of the sample to enable detection of the component. The power supply for driving the electrolyte in the tube is controlled by a control system in response to the detector signal to reduce the voltage, turn the power supply off or apply a voltage of opposite polarity in order to increase the residence time of a particular component which has been detected or to make it pass the detector region two or more times. By increasing the residence time, the sensitivity of detection is increased.
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Frost John W.
Pentoney, Jr. Stephen L.
Quint Jeff
Zare Richard N.
Starsiak Jr. John S.
The Board of Trustees of the Leland Standford Junior University
Valentine Donald R.
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