Capillary electrophoresis of transferrin glycoforms

Details Capillary electrophoresis of transferrin glycoforms Capillary electrophoresis of transferrin glycoforms

1997-01-24

1999-11-30

Beisner, William H.

Chemistry: electrical and wave energy

Processes and products

Electrophoresis or electro-osmosis processes and electrolyte...

204454, 204455, 204601, 204605, G01N 2726, G01N 27447

Patent

active

059936266

ABSTRACT:
A capillary electrophoresis method for resolving transferrin glycoforms in a sample is described. The capillary comprises a lumen, an inlet and an outlet. The lumenal surface of the capillary is charge-neutral and the capillary contains a buffer containing a polymeric matrix. The transferrin sample is contacted with the inlet of the capillary. A voltage is applied to the capillary such that the inlet is a cathode and the outlet is an anode and such that the voltage is effective for resolving transferrin glycoforms. A method for diagnosing chronic alcoholism or carbohydrate-deficient glycoprotein syndrome using CE to resolve abnormal populations of transferrin glycoforms is also described.

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