Capillary electrophoresis method for screening for affinity...

Details Capillary electrophoresis method for screening for affinity... Capillary electrophoresis method for screening for affinity...

2005-01-04

2005-01-04

Diamond, Alan (Department: 1753)

Chemistry: electrical and wave energy

Processes and products

Electrophoresis or electro-osmosis processes and electrolyte...

C204S601000, C204S452000, C204S453000, C204S602000, C204S603000, C204S604000, C204S605000, C204S455000, C204S606000, C204S607000, C204S608000, C204S610000, C204S612000, C204S615000, C204S616000, C204S617000, C204S618000, C204S621000, C436S516000, C436S538000, C436S540000, C436S501000, C435S007100

Reexamination Certificate

active

06837977

ABSTRACT:
The invention relates to a capillary electrophoresis-based method of screening complex materials for any unidentified affinity ligand that binds to a target of interest. The method subjects a plug of a mixture of the target and a complex material sample, and a separate plug of a known, tight-binding competitive ligand, to capillary electrophoresis under conditions optimized to allow mingling of the two plugs during the capillary electrophoresis run. Preferably, migration of the competitive ligand is tracked.

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