Capillary electrophoresis method and apparatus for electric fiel

Details Capillary electrophoresis method and apparatus for electric fiel Capillary electrophoresis method and apparatus for electric fiel

1995-02-28

1996-04-30

Niebling, John

Chemistry: electrical and wave energy

Processes and products

Electrophoresis or electro-osmosis processes and electrolyte...

204455, 204459, 204604, 204605, 204610, G01N 2726, G01N 27447

Patent

active

055121586

ABSTRACT:
A capillary electrophoresis method and apparatus for reducing dispersion of sample fractions are disclosed. The capillary tube in which the electrophoresis is performed has been flared, at least at its sample entrance end, to remove sharp corners which contribute to aberrations in the electric field distribution in a radial direction and result in differential migration of molecules depending on their proximity to the sharp corners. The flared tube, in contrast to a conventional tube, provides a more uniform electric field for electrophoresis and reduces undesired dispersion of the samples.

REFERENCES:
patent: 5290587 (1994-03-01), Young et al.
patent: 5296116 (1994-03-01), Guttman
patent: 5324413 (1994-06-01), Gordon
Sandra Sloss and Andrew G. Ewing "Improved Method for End-Column Amperometric Detection for Capillary Electrophoresis" Analytical Chemistry, vol. 65, No. 5 (Mar. 1, 1993) 577-581.

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