Capillary electrophoresis electrospray ionization mass spectrome

Chemistry: electrical and wave energy – Apparatus – Electrophoretic or electro-osmotic apparatus

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204450, 250288, G01N 2726

Patent

active

059936339

ABSTRACT:
The present invention is an interface between a capillary electrophoresis separation capillary end and an electrospray ionization mass spectrometry emitter capillary end, for transporting an anolyte sample from a capillary electrophoresis separation capillary to a electrospray ionization mass spectrometry emitter capillary. The interface of the present invention has: (a) a charge transfer fitting enclosing both of the capillary electrophoresis capillary end and the electrospray ionization mass spectrometry emitter capillary end; (b) a reservoir containing an electrolyte surrounding the charge transfer fitting; and (c) an electrode immersed into the electrolyte, the electrode closing a capillary electrophoresis circuit and providing charge transfer across the charge transfer fitting while avoiding substantial bulk fluid transfer across the charge transfer fitting. Advantages of the present invention have been demonstrated as effective in providing high sensitivity and efficient analyses.

REFERENCES:
Severs et al. ("A New High-perfromance Interface for Capillary Electrophoresis/Electrospray ionization Mass Spectrometry", Rapid Communications in MAss Spectrometry, vol. 10, 1175-1178, month unknown. 1996).
Lamoree et al. ("On-line coupling of micellar electrokinetic chromatography to electrospray mass spectrometry", Journal of Chromatography A, 712 (month unknown 1995) 219-2250 month unknown.
Lamoree et al. ("Use of heptakis92,6-di-o-methyl)B-cyclodextrin in on-line capillary zone electrophoresis-mass spectrometry for the chiral separation of ripivacaine", Journal of Chromathography A, 742 (month unknown 1996) 235-242).
Liquid Junction Coupling for Capillary Zone Electrophoresis/Ion Spray Mass Spectrometry, ED Lee, W Much, JD Henion, TR Covey, Biomedical and Environmental Mass Spectromety, vol. 18, 844-850 (1989) Month unknown.

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