Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant...
Patent
1988-12-19
1991-02-12
Maples, John S.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
436 56, 128654, 250303, G01N 3700, A61B 600
Patent
active
049922556
ABSTRACT:
A method for quantifying transcytosis through the blood-brain barier by infusing a perfusate into the brain of a living mammal. The perfusate includes a radio-labelled test compound and a radio-labelled marker compound. The perfused brain is removed from the animal and homogenized. The homogenized brain is separated into a microvasculature fraction and a supernatant fraction. The net volume of distribution of the test compound in the supernatant is calculated and corrected to provide an accurate measure of transcytosis through the blood brain barrier.
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