Chemistry: electrical and wave energy – Processes and products – Electrostatic field or electrical discharge
Patent
1992-05-15
1994-12-06
Niebling, John
Chemistry: electrical and wave energy
Processes and products
Electrostatic field or electrical discharge
2041801, 204299R, G01N 2726, G01N 27447
Patent
active
053707770
ABSTRACT:
Disclosed herein are capillary columns for capillary electrophoretic analysis of sample constituents. In an embodiment, the columns comprise a bifunctional layer comprising a positively charged amine group adsorbed to the inner wall of the capillary and an active functional group; a gel composition; hydrophilic polymer; and a separation composition capable of being removed from the column, interspersed within the remainder of the column. The disclosed columns are particularly well suited for the analysis of surfactant: proteinaceous material complexes, nucleic acid sequence, and analysis of restriction fragments according to size.
REFERENCES:
patent: 4657656 (1987-04-01), Ogawa
patent: 4680201 (1987-07-01), Hjerten
patent: 4729947 (1988-03-01), Middendorf et al.
patent: 4865706 (1989-09-01), Karger et al.
patent: 4865707 (1989-09-01), Karger et al.
patent: 4959134 (1990-09-01), Gross et al.
patent: 4962020 (1990-10-01), Tabor et al.
patent: 4997537 (1991-03-01), Karger et al.
patent: 5011769 (1991-04-01), Duck et al.
patent: 5015350 (1991-05-01), Wiktorowicz
patent: 5045172 (1991-09-01), Guzman
patent: 5061336 (1991-10-01), Soane
patent: 5064519 (1991-11-01), Tice, Jr. et al.
patent: 5068176 (1991-11-01), Vijg et al.
patent: 5089111 (1992-02-01), Zhu et al.
patent: 5096554 (1992-03-01), Chin
patent: 5098539 (1992-03-01), Shieh
patent: 5110424 (1992-05-01), Chin
Martin, Richard; "Overcoming DNA Sequencing Artifacts: Stops and Compressions"; Focus 9:1; pp. 8-10.
Martin, Richard; "Overcoming DNA Sequencing Artifacts: G-C Homopolymer Tails"; Focus 9:2; pp. 7-8.
Smith, Lloyd M.; "DNA Sequence Analysis: Past, Present and Future"; (May 1989); pp. 10-25.
Luckey, John A., et al.; "High Speed DNA Sequencing by Capillary Electrophoresis"; Nucleic Acids Research, vol. 18, No. 15, Jun. 15, 1990; pp. 4417-4421.
Drossman, Howard, et al.; "High-Speed Separations of DNA Sequencing Reactions by Capillary Electrophoresis"; Anal. Chem. 1990, pp. 900-903.
Cunningham, Philip R. and James Ofengand; "A Method for the Deterination of Sequence of High G+C% DNA by the Sequential Application of Sequenase and Taq Polymerase"; 714 BioTechniques, vol. 9, No. 6 (1990).
Article --"Sequencing Gel Compressions".
Article from Fourth International Symposium on High Performance Capillary Electrophoresis, Feb. 9-13, 1992, RIA Congress Centre, Amsterdam, p. 69.
Hjerten, Stellan; "High Performance Electrophoresis Elimination of Electroendosmosis and Solute Adsorption"; Journal of Chromatography, 347, pp. 191-198.
Cobb, Kelly A., et al., "Electrophoretic Separations of Proteins in Capillaries with Hydrolytically Stable Surface Structures"; Anal Chem. 1990, vol. 62, No. 22, pp. 2478-2483.
Good, Norman E., et al.; "Hydrogen Ion Buffers for Biological Research"; vol. 5, No. 2, Feb. 1966, pp. 467-477.
Bode, Hans-Joachim; "SDS-Polyethyleneglycol Electrophoresis: A Possible Alternative to SDS-Polyacrylamide Gel Electrophoresis"; FEBS Letters, vol. 65, No. 1 (May 1976), pp. 56-58.
Widhalm, Alexandra, et al.; "Capillary Zone Electrophoresis with a Linear, Non-cross linked Polyacrylamide Gel: Separation of Proteins According to Molecular Mass"; Journal of Chromatography, 549 (1991) pp. 446-451.
Tsuji, Kiyoshi; "High-performance Capillary Electrophoresis or Proteins-Sodium dodecyl sulphate-polyacrylamide gel-filled capillary column for the determination of recombinant biotechnology-derived proteins"; Journal of Chromatography, 550 (1991), pp. 823-830.
Ulfelder, Kathi J., et al.; "Restriction Fragment Length Polymorphism Analysis of ERBB2 Oncogene by Capillary Electrophoresis"; Analytical Biochemistry 200, (1992), pp. 260-267.
Ganzler Katalin
Guttman Andras
Karger Barry L.
Konrad Kenneth D.
Pentoney, Jr. Stephen J.
Beckman Instruments Inc.
Harder P. R.
Henry Janis C.
May William H.
Niebling John
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