Capillary array electrophoresis scanner

Chemistry: electrical and wave energy – Processes and products – Electrophoresis or electro-osmosis processes and electrolyte...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C204S603000

Reexamination Certificate

active

07090758

ABSTRACT:
An improved rotary confocal fluorescence scanner capable of detecting analytes separated on over a 1,000 capillaries simultaneously. This system uses a confocal microscope objective and mirror assembly that rotates inside a vertical ring of capillaries to provide rapid and efficient excitation and detection of fluorescently labeled fragments separated within a cylindrical capillary array. Use of automated procedures to load and run all capillaries permits one to read more than 350,000 base pairs of raw sequence data per hour.

REFERENCES:
patent: 5091652 (1992-02-01), Mathies et al.
patent: 5274240 (1993-12-01), Mathies et al.
patent: 5354538 (1994-10-01), Bunce et al.
patent: 5372695 (1994-12-01), Demorest
patent: 5443791 (1995-08-01), Cathcart et al.
patent: 5483075 (1996-01-01), Smith et al.
patent: 5540888 (1996-07-01), Bunce et al.
patent: 5560811 (1996-10-01), Briggs et al.
patent: 5770157 (1998-06-01), Cargill et al.
patent: 6103083 (2000-08-01), Merenkova et al.
patent: 6120667 (2000-09-01), Hayashizaki et al.
patent: 6270644 (2001-08-01), Mathies et al.
patent: 6554986 (2003-04-01), Mathies et al.
patent: 09-243597 (1997-09-01), None
JPO computer generated English language translation of Shin et al. (JP 09-243597 A).
Swerdlow et al. (Three DNA Sequencing Methods Using Capillary Gel Electrophoresis and Laser-Induced Fluorescence, Anal. Chem. 1991, 63, 2835-2841).
Dichroic Beam splitters article from CVI Laser Optics and Coatings website, downloaded on Dec. 21, 2005.
Smith et al., 1986, 321Nature674-679 Jun.
Swerdlow, H. & Gesteland, R., 1990, 18Nuc. Acid Research1415-1419.
Luckey et al, 1990, 18Nuc. Acids Res.4417-4421.
Cohen, A.S. et al., 1990, 516Journal of Chromatography49-60.
Mathies, R.A. & Huang, X.C., 1992, 359Nature, 167-169, Sep.
E.C. Buxton et al., “Automation in large-scale DNA sequencing,”Laboratory Robotics and Automation 8(Abstract) (1996).
Woolley, A. and Mathies, R., “Ultra-high-speed DNA fragment separations using microfabricated capillary array electrophoresis chips,” 91Proc. Natl. Acad. Sci USA, 11348-11352, Nov. 1994.
Watson, et al., “TheCaenorhabditis elegansgenome sequencing project: first steps in automation,” 362Nature, 569-570, Apr.
Hawkins, et al., “A Magnetic Attraction to High-Throughput Genomics,” 276Science, 1887-1889 Jun.
Panussis, et al., “A Pneumatic Device for Rapid Loading DNA Sequencing Gels,”Genome Research(1998), 543-548.
Harrison, D., “Proceedings of the uTAS '98 Workshop, held in Banff, Canada, Oct. 13-16, 1998,”Micro Total Analysis Systems '98, 1-7.
Seiler, et al., “Planar Glass Chips for Capillary Electrophoresis: Repetitive Sample Injection, Quantitation, and Separation Efficiency,”Anal. Chem.1993, 65, 1481-1488 May.
Woolley, A. and Mathies, R., “Ultra-high-speed DNA Sequencing Using Capillary Electrophoresis Chips,”Analytical Chemistry, vol. 67, No. 20, Oct. 15, 1995, pp. 3676-3680 Oct.
Kheterpal, et al., “DNA sequencing using a four-color confocal fluorescence capillary array scanner,”Electrophoresis1996, 17, 1852-1859.
D. Schmalzing et al., “DNA Sequencing on Microfabricated Electrophoretic Devices,”Anal. Chem.1998, 70, 2303-2310, Jun.
D. Schmalzing, et al., “DNA typing in thirty seconds with a microfabricated device,”Proc. Natl. Acad. Sci. USA, vol. 94, Sep. 1997, pp. 10273-10278.
Simpson, et al., “High-throughput genetic analysis using microfabricated 96-sample capillary array electrophoresis microplates,”Proc. Natl. Acad. Sci. USA, vol. 95, Mar. 1998, pp. 2256-2261.
Woolley, et al., “High-speed DNA Genotyping Using Microfabricated Capillary Array Electrophoresis Chips,”Analytical Chemistry, vol. 69, No. 11, pp. 2181-2186, Jun. 1997.
Scherer, et al., “Ultra-high throughput rotary capillary array electrophoresis scanner for fluorescent DNA sequencing and analysis,”Electrophoresis1999, 20, 1508-1517, Jun.
Bevan, C. and Mutton, I., “Use of Freeze-Thaw Flow Management for Controlling and Switching Fluid Flow in Capillary Tubes,” 67Anal. Chem, 1470-1473 (1995) Apr.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Capillary array electrophoresis scanner does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Capillary array electrophoresis scanner, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Capillary array electrophoresis scanner will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3621038

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.