Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2006-11-28
2006-11-28
Weber, Jon (Department: 1653)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Reexamination Certificate
active
07141650
ABSTRACT:
A novel polypeptide which is useful in screening of an agent for improving insulin resistance and an agent for improving glucose metabolism, a polynucleotide encoding the polypeptide, an expression vector comprising the polynucleotide, and a cell transformed with the expression vector are disclosed. The polypeptide is a protein expressed in skeletal muscle. When the protein is overexpressed, incorporation of sugar into a cell is inhibited.A method for screening of an agent for improving insulin resistance and/or an agent for improving glucose metabolism in which the polypeptide is used, and a method for producing a pharmaceutical composition for insulin resistance and/or glucose metabolism improvement comprising a substance obtained according to the method for screening as an active ingredient are also disclosed.
REFERENCES:
patent: WO 03/23002 (2003-03-01), None
GENBANK: BQ070301—Apr. 2, 2002.
Sequence alignment, BQ070301 and Seq Id No. 2.
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Liu, Jun, et al., “APS facilities c-Cbl tyrosine phosphorylation and GLUT4 translocation in repsonse to insulin in 3T3-L1 adipocytes”, Molecular and Cellular Biology, vol. 22, No. 11, Jun. 2002, pp. 3599-3609.
Endoh Hideki
Inabe Kazunori
Oda Tamaki
Ueda Yoshitaka
Astellas Pharma Inc.
Noakes Suzanne M.
Sughrue & Mion, PLLC
Weber Jon
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