Cannabinoid receptor antagonists/inverse agonists useful for...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C548S379100, C548S379400, C548S379700

Reexamination Certificate

active

07655685

ABSTRACT:
The present invention provides novel pyrazoles that are useful as cannabinoid receptor antagonists and pharmaceutical compositions thereof and methods of using the same for treating obesity, diabetes, hepatic disorders, and/or cardiometabolic disorders.

REFERENCES:
patent: 6476060 (2002-11-01), Lange et al.
patent: 6974810 (2005-12-01), Lange et al.
patent: 7482470 (2009-01-01), McElroy et al.
patent: 7528162 (2009-05-01), Kruse et al.
patent: 2004/0248944 (2004-12-01), Kruse et al.
patent: 2007/0213302 (2007-09-01), McElroy et al.
patent: 2009/0036511 (2009-02-01), McElroy et al.
patent: 1429761 (2006-11-01), None
PCT/US08/82173 International Search Report and Written Opinion.
Lange, J.H.M. et al.; Synthesis, Biological Properties and Molecular Investigations of Novel 3,4-Diarylpyrazolines as Potent and Selective CB1 Cannabinoid Receptor Antagonists; J. Med. Chem. 2004, 47, 627-643.

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