Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-05-31
2005-05-31
Solola, Taofiq (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S483000, C548S484000
Reexamination Certificate
active
06900236
ABSTRACT:
Novel cannabimimetic indole derivatives are presented which have preferential high affinities for one of the cannabinoid CB1 CB2 receptor sites. The improved receptor affinity makes these analogs therapeutically useful as medications in individuals and animals for treatment of pain, glaucoma, epilepsy, nausea associated with chemotherapy.
REFERENCES:
patent: 3041343 (1962-06-01), Jucker et al.
patent: 3465024 (1969-09-01), Brownstein et al.
patent: 3573327 (1971-03-01), Miyano
patent: 3577458 (1971-05-01), Brownstein et al.
patent: 3656906 (1972-04-01), Bullock
patent: 3886184 (1975-05-01), Matsumoto et al.
patent: 3897306 (1975-07-01), Vidic
patent: 3915996 (1975-10-01), Wright
patent: 3928598 (1975-12-01), Archer
patent: 3944673 (1976-03-01), Archer
patent: 3953603 (1976-04-01), Archer
patent: 4036857 (1977-07-01), Razdan et al.
patent: 4054582 (1977-10-01), Blanchard et al.
patent: 4087545 (1978-05-01), Archer et al.
patent: 4087546 (1978-05-01), Archer et al.
patent: 4087547 (1978-05-01), Archer et al.
patent: 4088777 (1978-05-01), Archer et al.
patent: 4102902 (1978-07-01), Archer et al.
patent: 4152450 (1979-05-01), Day et al.
patent: 4171315 (1979-10-01), Ryan
patent: 4176233 (1979-11-01), Archer et al.
patent: 4179517 (1979-12-01), Mechoulam et al.
patent: 4188495 (1980-02-01), Althuis et al.
patent: 4208351 (1980-06-01), Archer et al.
patent: 4278603 (1981-07-01), Thakkar
patent: 4282248 (1981-08-01), Mechoulam et al.
patent: 4382943 (1983-05-01), Winter et al.
patent: 4395560 (1983-07-01), Ryan
patent: 4497827 (1985-02-01), Nelson
patent: 4550214 (1985-10-01), Mehta
patent: 4758597 (1988-07-01), Martin et al.
patent: 4812457 (1989-03-01), Narumiya et al.
patent: 4876276 (1989-10-01), Mechoulam et al.
patent: 4885295 (1989-12-01), Bell
patent: 5053548 (1991-10-01), Tanaka et al.
patent: 5068234 (1991-11-01), D'Ambra et al.
patent: 5147876 (1992-09-01), Mizuchi et al.
patent: 5284867 (1994-02-01), Kloog et al.
patent: 5324737 (1994-06-01), D'Ambra et al.
patent: 5434295 (1995-07-01), Mechoulam et al.
patent: 5440052 (1995-08-01), Makriyannis et al.
patent: 5462960 (1995-10-01), Barth et al.
patent: 5489580 (1996-02-01), Makriyannis et al.
patent: 5521215 (1996-05-01), Mechoulam et al.
patent: 5532237 (1996-07-01), Gallant et al.
patent: 5538993 (1996-07-01), Mechoulam et al.
patent: 5605906 (1997-02-01), Lau
patent: 5607933 (1997-03-01), D'Ambra et al.
patent: 5618955 (1997-04-01), Mechoulam et al.
patent: 5624941 (1997-04-01), Barth et al.
patent: 5635530 (1997-06-01), Mechoulam et al.
patent: 5688825 (1997-11-01), Makriyannis et al.
patent: 5744459 (1998-04-01), Makriyannis et al.
patent: 5747524 (1998-05-01), Cullinan et al.
patent: 5804601 (1998-09-01), Kato et al.
patent: 5817651 (1998-10-01), D'Ambra et al.
patent: 5872148 (1999-02-01), Makriyannis et al.
patent: 5874459 (1999-02-01), Makriyannis et al.
patent: 5925628 (1999-07-01), Lee et al.
patent: 5925768 (1999-07-01), Barth et al.
patent: 5932610 (1999-08-01), Shohami et al.
patent: 5948777 (1999-09-01), Bender et al.
patent: 6013648 (2000-01-01), Rinaldi et al.
patent: 6028084 (2000-02-01), Barth et al.
patent: 6096740 (2000-08-01), Mechoulam et al.
patent: 6127399 (2000-10-01), Yuan
patent: 6166066 (2000-12-01), Makriyannis et al.
patent: 6284788 (2001-09-01), Mittendorf et al.
patent: 6391909 (2002-05-01), Makriyannis et al.
patent: 6579900 (2003-06-01), Makriyannis et al.
patent: 6610737 (2003-08-01), Garzon et al.
patent: 2002/0119972 (2002-08-01), Leftheris et al.
patent: 2003/0120094 (2003-06-01), Makriyannis et al.
patent: 2003/0149082 (2003-08-01), Makriyannis et al.
patent: 2004/0077649 (2004-04-01), Makriyannis et al.
patent: 2004/0077851 (2004-04-01), Makriyannis et al.
patent: 2004/0087590 (2004-05-01), Makriyannis et al.
patent: 0276732 (1988-08-01), None
patent: 0737671 (1996-10-01), None
patent: 0 860 168 (1998-08-01), None
patent: 2240003 (1975-05-01), None
patent: 2735774 (2000-01-01), None
patent: 2027021 (1980-02-01), None
patent: 357098228 (1982-06-01), None
patent: 2304080 (1990-12-01), None
patent: WO 99/57107 (1999-11-01), None
patent: WO 99/64389 (1999-12-01), None
patent: WO 00/32200 (2000-06-01), None
patent: WO 01/28329 (2001-04-01), None
patent: WO 01/28497 (2001-04-01), None
patent: WO 01/28498 (2001-04-01), None
patent: WO 01/29007 (2001-04-01), None
patent: WO 01/32169 (2001-05-01), None
patent: WO 03/005960 (2003-01-01), None
patent: WO 03/020217 (2003-03-01), None
patent: WO 03/035005 (2003-05-01), None
patent: WO 03/063758 (2003-08-01), None
patent: WO 03/064359 (2003-08-01), None
C-Attached Aminoalkylindoles; Potent Cannabinoid Mimetics; Thomas E. D'ambra et al; Biorganic & Medicinal Chemistry Letters, vol. 6, No. 1 pp. 17-22, 1996.
Evaluation Of Binding In A Transfected Cell Line Expressing A Peripheral Cannabinoid Receptor (CB2): Indentification Of Cannabinoid Receptor Subtype Selective Ligands; Vincent M. Showalter et al; The Journal of Pharmacology and Experimental Therapeutics, vol. 278, No. 3; pp. 989-999. XP 001097918, (1996).
Pharmacological Characterization Of Three Novel Cannabinoid Receptor Agonists In The Mouse Isolated Vas Deferens; Roger G. Pertwee et al; XP-001041044; European Journal of Pharmacology 284 (1995) pp. 241-247.
Aminoalkylindoles: Structure-Activity Relationships Of Novel Cannabiniod Mimetics; Michael A. Eissenstat et al.; XP 000851090; J. Med. Chem 1995, 38, pp. 3094-3105.
Three-Dimensional Quantitative Structure-Activity Relationship Study Of The Cannabimimetic (Aminoalkylindoles Using Comparative Molecular Field Analysis; XP-002212407; Joong-Youn Shim et al; J. Med. Chem 1998; 41, pp. 4521-4532.
AM630, A Competitive Cannabinoid Receptor Antagonist; XP 000653566; Roger Pertwee et al, Life Sciences, vol. 56, Nos. 23/24, pp. 1949-1955, 1995.
Unified Pharmacophoric Model For Cannabinoids And Aminoalkylindoles Derived From Molecular Superimposition Of CB1 Cannabinoid Receptor Agonists CP55244 and WIN55212-2, Joong-Youn Shim et al; American Chemical Society; pp. 165-184; XP-001095771, (1999).
Structure-Activity Relationships of Indole-And Pyrrole-Derived Cannabinoids; XP 001097982; Jenny L. Wiley et al.; The Journal of Pharmacology and Experimental Therapeutics; pp 995-1004; Vol 285; No. 3, (1998).
International Publication WO 97/00860, CB2 Receptor Agonist Compounds; Murielle Rinaldi et al, Published Jan. 9, 1997.
Pacheco M, et al; “Aminoalkylindoles: Actions On Specific G-Protein-Linked Receptors”; J. Pharmacol. Exp. Ther.; vol. 257, No. 1, pp. 170-183 and 172 Table (1991).
Tetko, I. V. et al; “Volume Learning Algorithm Artificial Neural Networks For 3D QSAR Studies”; J. Med. Chem.; vol. 44, No. 15 (2001) pp. 2411-2420, 2413, 2414 Table 1.
Abadji V., Lin S., Taha G., Griffin G., Stevenson L.A., Pertwee R.G., Makriyannis A.; “(R)-Methanadamie: a chiral novel anandamide possessing higher potency and metabolic stability”; J. Med. Chem.; 37(12); 1889-1893; 1994; CODEN: JMCMAR; ISSN: 0022-2623; XP002040932.
Alo, B.I.; Kandil, A.; Patil, P. A.; Sharp, M. J.; Siddiqui, M. A.; and Snieckus, V. Sequential Directed Ortho Metalation-Boronic Acid Cross-Coupling Reactions. A general Regiospecific Route to Oxygenerated Dibenzo[b,d]pyran-6-ones Related to Ellagic Acid, J. Org. Chem. 1991, 56, 3763-3768.
Arnone M., Maruani J., Chaperon P, et al, Selective Inhibition of sucrose and ethanol intake by SR141716, an antagonist of central cannabinoid (CB1) receptors, Psychopharmacal, (1997) 132, 104-106 (abstract only).
Barnett-Norris et al; “Exploration of biologically relevant conformations of anandamide, . . . ”; J. Med. Chem.; vol. 41, 4861-4872; 1998.
Beak, P.; Brown, R. A., The Tertiary Amide as an Effective Director of Ortho Lithiation, J. Org. Chem. 1982, 47, 34-36.
Belgaonkar et al; “synthesius of isocoumarins”; Indian J. Chem.; vol. 13, No. 4, 336-338; 1975 (abstract only).
Beltramo M., Stella N., Calignano A., Lin S. Y., Makriyannis A., Piomelli D; “Functional Role Of High-Affinity Anandamide Transport, as Revealed By Selective Inhibition”; Science; vol. 277; 1094-1097;
Deng Hongfeng
Makriyannis Alexandros
Alix Yale & Ristas, LLP
Solola Taofiq
University of Connecticut
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