Canine COX-1 nucleic acid molecules and fragments thereof

Details Canine COX-1 nucleic acid molecules and fragments thereof Canine COX-1 nucleic acid molecules and fragments thereof

2007-05-29

2007-05-29

Achutamurthy, P. (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Oxidoreductase

C435S004000, C435S006120, C435S440000, C435S069100, C435S071100, C435S252300, C435S320100, C536S023200, C536S023500

Reexamination Certificate

active

10679140

ABSTRACT:
The present invention relates to canine COX-1 and COX-2 proteins; to canine COX-1 and COX-2 nucleic acid molecules, including those that encode such COX-1 and COX-2 proteins, respectively; to antibodies raised against such proteins; and to compounds that inhibit the activity of such proteins. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. The present invention also includes therapeutic compositions comprising such inhibitory compounds, particularly those that specifically inhibit COX-2 activity, as well as the use of such therapeutic compositions to treat animals.

REFERENCES:
Takahashi et al. Immunoaffinity purification and cDNA cloning of human platelet prostaglandin endoperoxide synthase (cyclooxygenase). Biochem Biophys Res Commun. Jan. 31, 1992;182(2):433-8.
Branden et al. (introduction to Protein Structure, Garland Publishing Inc., New York, p. 247, 1991).
Takahashi et al. Sequence Alignment—SEQ ID NO. 9, SEQ ID NO. 11, SEQ ID NO. 12, SEQ ID NO. 13, SEQ ID NO. 14, SEQ ID NO. 15 and SEQ ID NO. 16, pp. 15, 1992.
Guo et al. Protein tolerance to random amino acid change. Proc Natl Acad Sci U S A. Jun. 22, 2004;101(25):9205-10. Epub Jun. 14, 2004.
Dubois et al., 1998,The FASEB Journal, vol. 12, pp. 1063-1072.
Giuliano et al., 1999,British Journal of Pharmacology, vol. 126, pp. 1824-1830.
Golden et al., 1999,Rheumatic Disease Clinics of North America, vol. 25, No. 2, pp. 359-378.
Khan et al., 1998,Toxicologic Pathology, vol. 26, No. 5, pp. 612-620.
Laufer et al., 1999.,Inflamm. res., vol. 48, pp. 133-138.
Masferrer et al., 1994,Proc. Natl. Acad. Sci. USA, vol. 91, pp. 3228-3232.
Ricketts et al., 1998,AJVR, vol. 59, No. 11, pp. 1441-1446.
Riendeau et al., 1997,Can. J. Physiol. Pharmacol.vol. 75, pp. 1088-1095.
Seibert et al., 1994,Proc. Natl. Acad. Sci. USA, vol. 91, pp. 12013-12017.
Vane et al., 1998,Annu. Rev. Pharmacol. Toxicol., vol. 38, pp. 97-120.
Vane et al., 1995,Inflamm Res, vol. 44, pp. 1-10.
Warner et al., 1999,Proc. Natl. Acad. Sci. USA, vol. 96, pp. 7563-7568.

Affiliated with

Also associated with

Rating

Canine COX-1 nucleic acid molecules and fragments thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Canine COX-1 nucleic acid molecules and fragments thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Canine COX-1 nucleic acid molecules and fragments thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3766151