Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2006-01-13
2010-06-01
Pak, Michael (Department: 1646)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Reexamination Certificate
active
07728107
ABSTRACT:
Canine 5-hydroxytryptamine 2 receptor materials are described, including polypeptides corresponding to SEQ ID NOs.:8 and 10 and polynucleotides expressing them corresponding to SEQ ID NOs.:7 and 9. Such materials are useful as reagents in drug screening assays to identify compounds having 5-HT2receptor-modulating activity.
REFERENCES:
patent: 5360735 (1994-11-01), Weinshank et al.
patent: 5661024 (1997-08-01), Kao et al.
Adner et al., “An Assay to Evaluate the Long-Term Effects of Inflammatory Mediators on Murine Airway Smooth Muscle: Evidence that TNFα Up-Regulates 5-HT2A-Mediated Contraction”,Br J Pharmacol., 2002, vol. 137, pp. 971-982.
Aubert et al., “5-HT2Receptor Gene Polymorphism is Associated with Food and Alcohol Intake in Obese People”,Int J Obes., 2000, vol. 24, pp. 920-924.
Baluta et al., “Renin-Angiotensin-Aldosterone System Inhibition in Prevention of Diabetes Mellitus”,Rom J Intern Med., 2004, vol. 42(2), pp. 277-288.
Bhatnagar et al., “Caveolin-1 Interacts with 5-HT2ASerotonin Receptors and Profoundly Modulates the Signaling of Selected Gαq-coupled Protein Receptors”,J Biol Chem., 2004, vol. 279(33), pp. 34614-34623.
Boehme et al., “Cutting Edge: Serotonin is a Chemotactic Factor for Eosinophils and Functions Additively with Eotaxin”,J Immunol., 2004, vol. 173, pp. 3599-3603.
Bonaventure et al., “Nuclei and Subnuclei Gene Expression Profiling in Mammalian Brain”,Brain Res., 2002, vol. 943, pp. 38-47.
Bush, “Effects of the Serotonin Antagonists, Cyproheptadine, Ketanserin and Mianserin, on Cyclic Flow Reductions in Stenosed Canine Coronary Arteries”,J Pharmacol Exp Ther., 1987, vol. 240(2), pp. 674-682.
Cazzola et al., “Effect of the Selective 5-HT2Antagonist Ketanserin on Adenosine-Induced Bronchoconstriction in Asthmatic Subjects”,Immunopharmacology, 1992, vol. 23, pp. 21-28.
Celada et al., “The Therapeutic Role of 5-HT1Aand 5-HT2AReceptors in Depression”,J Psychiatry Neurosci., 2004, vol. 29(4), pp. 252-265.
Cohen et al., “Evidence for 5-HT2Receptors Mediating Contraction in Vascular Smooth Muscle”,J Pharmacol Exp Ther., 1981, vol. 218(2), pp. 421-425.
De Chaffoy de Courcelles et al., “Evidence that Phospholipid Turnover is the Signal Transducing System Coupled to Serotonin-S2Receptor Sites”,J Biol Chem., 1985, vol. 260(12), pp. 7603-7608.
Du et al., “Association of Polymorphism of Serotonin 2A Receptor Gene with Suicidal Ideation in Major Depressive Disorder”,Am J Med Genet., 2000, vol. 96, pp. 56-60.
Duxon et al., “Evidence for Expression of the 5-Hydroxytryptamine-2B Receptor Protein in the Rat Central Nervous System”,Neuroscience, 1997, vol. 76(2), pp. 323-329.
Fitzgerald et al., “High-Affinity Agonist Binding Correlates with Efficacy (Intrinsic Activity) at the Human Serotonin 5-HT2Aand 5-HT2CReceptors: Evidence Favoring the Ternary Complex and Two-State Models of Agonist Action”,J Neurochem., 1999, vol. 72(5), pp. 2127-2134.
Foguet et al., “Cloning and Functional Characterization of the Rat Stomach Fundus Serotonin Receptor”,EMBO J., 1992, vol. 11(9), pp. 3481-3487.
Fonseca et al., “Distribution of Serotonin 2A, 2C, and 3 receptor mRNA in Spinal Cord and Medulla Oblongata”,Brain Res Mol Brain Res., 2001, vol. 89, pp. 11-19.
Giles et al., “Characterization of a 5-HT1B Receptor on CHO Cells: Functional Responses in the Absence of Radioligand Binding”,Br J Pharmacol., 1996, vol. 117, pp. 1119-1126.
Gonzales et al., “Hypoprolactinemia as Related to Seminal Quality and Serum Testosterone”,Arch Androl., 1989, vol. 23, pp. 259-265.
Hall et al., “Autoradiographic Localization of 5-HT2AReceptors in the Human Brain Using [3H]M100907 and [11C]M100907”,Synapse, 2000, vol. 38, pp. 421-431.
Hoyer et al., “Molecular, Pharmacological and Functional Diversity of 5-HT Receptors”,Pharmacol Biochem Behav., 2002, vol. 71, pp. 533-554.
Huang et al., “Ultrastructural Localization of Serotonin 2A and N-Methyl-D-Aspartate Receptors in Somata and Dendrites of Single Neurons within Rat Dorsal Motor Nucleus of the Vagus”,J Comp Neurol., 2003, vol. 455, pp. 270-280.
Jara et al., “Prolactin in Human Systemic Lupus Erythematosus”,Lupus, 2001, vol. 10, pp. 748-756.
Jerman et al., “Pharmacological Characterisation of Human 5-HT2Receptor Subtypes”,Eur J Pharmacol., 2001, vol. 414, pp. 23-30.
Kantor et al., “Increased Wakefulness, Motor Activity and Decreased Theta Activity After Blockade of the 5-HT2BReceptor by the Subtype-Selective Antagonist SB-215505”,Br J Pharmacol., 2004, vol. 142, pp. 1332-1342.
Kroeze et al., “Molecular Biology of Serotonin Receptors-Structure and Function at the Molecular Level”,Curr Top Med Chem., 2002, vol. 2, pp. 507-528.
Kursar et al., “Molecular Cloning, Functional Expression, and Pharmacological Characterization of a Novel Serotonin Receptor (5-Hydroxytryptamine2F) from Rat Stomach Fundus”,Mol Pharmacol., 1992, vol. 42, pp. 549-557.
Leysen, “5-HT2Receptors”,Curr Drug Targets—CNS Neurol Disord., 2004, vol. 3, pp. 11-26.
Massou et al., “Frontal 5-HT2AReceptors Studied in Depressive Patients During Chronic Treatment by Selective Serotonin Reuptake Inhibitors”,Psychopharmacology, 1997, vol. 133, pp. 99-101.
Masuda et al., “Sequencing of Canine 5-Hydroxytriptamine Receptor (5-HTR) 1B, 2A, 2C Genes and Identification of Polymorphisms in the 5-HTR1B Gene”,J Vet Med Sci., 2004, vol. 66(8), pp. 965-972.
Meltzer, “The Role of Serotonin in Antipsychotic Drug Action”,Neuropsychopharmacology, 1999, vol. 21(2S), pp. 106S-115S.
Meyer et al., “The Effects of Single Dose Nefazodone and Paroxetine upon 5-HT2ABinding Potential in Humans using [18F]-setoperone PET”,Psychopharmacology, 1999, vol. 144, pp. 279-281.
Ogawa et al., “Effects of R-10244, an Orally Active 5-HT2AReceptor Antagonist, in Rat Models of Peripheral Vascular Disease”,Vascul Pharmacol., 2004, vol. 41, pp. 7-13.
Pazos et al., “Mesulergine, A Selective Serotonin-2 Ligand in the Rat Cortex, Does Not Label These Receptors in Porcine and Human Cortex: Evidence for Species Differences in Brain Serotonin-2 Receptors”,Eur J Pharmacol., 1985, vol. 106, pp. 531-538.
Pazos et al., “The Binding of Serotonergic Ligands to the Porcine Choroid Plexus: Characterization of a New Type of Serotonin Recognition Site”, Eur J Pharmacol., 1985, vol. 106, pp. 539-546.
Prins et al., “Characterization of the Receptors Involved in the 5-HT-Induced Excitation of Canine Antral Longitudinal Muscle”,Br J Pharmacol., 2001, vol. 134, pp. 1351-1359.
Porter et al., “Functional Characterization of Agonists at Recombinant Human 5-HT2A, 5-HT2Band 5-HT2CReceptors in CHO-K1 cells”,Br J Pharmacol., 1999, vol. 128, pp. 13-20.
Rinaldi-Carmona et al., “Biochemical and Pharmacological Properties of SR 46349B, A New Potent and Selective 5-Hydroxytryptamine2Receptor Antagonist”,J Pharmacol Exp Ther., 1992, vol. 262(2), pp. 759-768.
Rittenhouse et al., “Evidence that the Serotonin Agonist, DOI, Increases Renin Secretion and Blood Pressure Through both Central and Peripheral 5-HT2Receptors”,J Pharmacol Exp Ther., 1991, vol. 259(1), pp. 58-65.
Rittenhouse et al., “Evidence that ACTH Secretion is Regulated by Serotonin2A/2C(5-HT2A/2C) Receptors”,J Pharmacol Exp Ther., 1994, vol. 271(3), pp. 1647-1655.
Roth et al., “5-Hydroxytryptamine2-Family Receptors (5-Hydroxytryptamine2A, 5-Hydroxytryptamine2B, 5-Hydroxytryptamine2C): Where Structure Meets Function”,Pharmacol Ther., 1998, vol. 79(3), pp. 231-257.
Saucier et al., “Identification of an Endogenous 5-Hydroxytryptamine2AReceptor in NIH-3T3 Cells: Agonist-Induced Down-Regulation Involves Decreases in Receptor RNA and Number”,J
Bonaventure Pascal
Liu Changlu
Lovenberg Timothy W.
Nepomuceno Diane
Janssen Pharmaceutica N.V.
Pak Michael
LandOfFree
Canine 5-hydroxytryptamine 2A and 2B receptor does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Canine 5-hydroxytryptamine 2A and 2B receptor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Canine 5-hydroxytryptamine 2A and 2B receptor will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4224351