Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2007-03-06
2007-03-06
Blanchard, David J. (Department: 1643)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S387300, C530S388800, C530S391300, C530S391700, C424S133100, C424S141100, C424S155100, C424S183100, C435S007230, C435S069600, C435S070210
Reexamination Certificate
active
10891866
ABSTRACT:
The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.
REFERENCES:
patent: 4861581 (1989-08-01), Epstein et al.
patent: 5171665 (1992-12-01), Hellstrom et al.
patent: 5484596 (1996-01-01), Hanna, Jr. et al.
patent: 5693763 (1997-12-01), Codington et al.
patent: 5750102 (1998-05-01), Eisenbach et al.
patent: 5780033 (1998-07-01), Torchilin et al.
patent: 5783186 (1998-07-01), Arakawa et al.
patent: 5849876 (1998-12-01), Linsley et al.
patent: 5869045 (1999-02-01), Hellstrom et al.
patent: 5869268 (1999-02-01), Kudo et al.
Campbell et al. Biology, 5th ed. p. 856, 1999.
Co et al. Nature, 351(6):501-502, Jun. 6, 1991.
Presta et al. Biochemical Society Transactions, 30(4):487-490, 2002.
T. Karpanen et al, “Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth”, Cancer Research, 61:1786-1790 (Mar. 2001).
W. Waud et al, “Characterization of in vivo mammary and prostate tumor xenograft models for growth and response to clinical anticancer agents”, Contrib Oncol Basel Karger, 54:305-315 (1999).
G. Klement et al, “Differences in therapeutic indexes of combination metronomic chemotherapy and an anti-VEGFR-2 antibody in multidrug-resistant human breast cancer xenografts”, Clinical Cancer Research, 8:221-232 (Jan. 2002).
D. Blakey et al, “Antitumor activity of the novel vascular targeting agent ZD6126 in a panel of tumor models”, Clinical Cancer Research, 8:1974-1983 (Jun. 2002).
Z. Xiao et al, “Generation of a baculovirus recombinant prostate-specific membrane antigen and its use in the development of a novel protein biochip quantitative immunoassay”, Protein Expresion and Purification, 19:12-21 (2000).
S. Guichard et al, “Schedule-dependent activity of topotecan in OVCAR-3 ovarian carcinoma xenograft: pharmacokinetic and pharmacodynamic evaluation”, Clinical Cancer Research, 7:3222-3228 (Oct. 2001).
V. Von Gruenigen et al, “Efficacy of intraperitoneal adenovirus-mediated p53 gene therapy in ovarian cancer”, Int. J. Gynecol. Cancer, 9:365-372 (1999).
N. Guilbaud et al, “Marked antitumor activity of a new potent acronycine derivative in orthotopic models of human solid tumors”, Clinical Cancer Research, 7:2573-2580 (Aug. 2001).
K. Olson et al, “Inhibition of prostate carcinoma establishment and metastatic growth in mice by an antiangiogenin monoclonal antibody”. Int. J. Cancer, 98:923-929 (2002).
S. Hirschfeld et al, “Oncology drug development: United States Food and Drug Administration perspective”, Critical Reviews in Oncology/Hematology, 42:137-143 (2002).
P. Therasse et al, “New guidelines to evaluate the response to treatment in solid tumors”, Journal of the National Cancer Institute, 92(3):205-216 (Feb. 2000).
G. Eckhardt et al, “Developmental therapeutics: successes and failures of clinical trial designs of targeted compounds”, in American Society of Clinical Oncology, pp. 209-219 (2003).
P. Smith et al, “Anti-interleukin-6 monoclonal antibody induces regression of human prostate cancer xenografts in nude mice”, The Prostate, 48:47-53 (2001).
M. Chatterjee et al, “Idiotypic antibody immunotherapy of cancer”, Cancer Immunol Immunother, 38:75-82 (1994).
R. Jain, “Barriers to drug delivery in solid tumors”, Scientific American, 271(1):58-65 (Jul. 1994).
L. Presta et al, “Engineering therapeutic antibodies for improved function”, Biochemical Society Transactions, 30(4):487-490 (2002).
S. Shak, “Overview of the trastuzumab (Herceptin) anti-HER2 monoclonal antibody clinical program in HER2-overexpressing metastatic breast cancer”, Seminars in Oncology, 26(4 Suppl 12):71-77 (Aug. 1999).
S. Seaver, “Monoclonal antibodies in industry: more difficult than originally thought”, Genetic Engineering News, 14(14):pp. 10 and 21 (1994).
L. Weiner, “An overview of monoclonal antibody therapy of cancer”, Seminars in Oncology, 26(4 Suppl 12):41-50 (Aug. 1999).
Findlay Helen P.
Hahn Susan E.
Young David S. F.
Arius Research Inc.
Blanchard David J.
McHale & Slavin P.A.
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