Cancer treatments including administering IL-2 fusion...

Details Cancer treatments including administering IL-2 fusion... Cancer treatments including administering IL-2 fusion...

2006-10-16

2008-12-09

Mertz, Prema (Department: 1646)

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

C514S002600, C514S008100, C514S012200

Reexamination Certificate

active

07462350

ABSTRACT:
The invention provides cytokine fusion proteins with an increased therapeutic index, and methods to increase the therapeutic index of such fusion proteins. The fusion proteins of the invention are able to bind to more than one type of cytokine receptor expressed on cells and also bind to more than one cell type. In addition, the fusion proteins of the invention exhibit a longer circulating half-life in a patient's body than the corresponding naturally occurring cytokine.

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