Cancer treatment with temozolomide

Details Cancer treatment with temozolomide Cancer treatment with temozolomide

1997-07-29

1999-08-17

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

514183, A61K 3133

Patent

active

059390980

ABSTRACT:
There is disclosed a method for treating cancer in a patient in need of such treating comprising administering temozolomide in an amount sufficient to achieve a clinical response wherein the temozolomide is administered more than once per day. Preferred specific dosing schedules are provided.

REFERENCES:
patent: 5731304 (1998-03-01), Baer et al.
Newlands et al., The Charing Cross Hospital Experience with Temozolomide in Patients with Gliomas, European Journal of Cancer, vol. 32A, No. 13, pp. 2236-2241, Dec. 1996.
Newlands, British J. Cancer, 65(2), 287-292 (1992).
Bleehen et al, J. Clinical Oncology, 13(4), 910-913 (1994).
O'Reilly et al, European J. cancer, 29A, 940 (1993).
Stevens et al, J. Medicinal Chem., 27, 196-201 (1984).
Wang et al, J. Chem. Soc.--Chem. Comm., 1687-1688 (1994).

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