Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,...
Reexamination Certificate
2003-08-15
2009-12-01
Goddard, Laura B (Department: 1642)
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
C424S181100
Reexamination Certificate
active
07625563
ABSTRACT:
Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread, and compositions and methods for utilizing these findings in the treatment of cancer and viral infections. Also disclosed are advantageous antibody, immunoconjugate and duramycin-based compositions and combinations that bind and inhibit anionic phospholipids and aminophospholipids, for use in the safe and effective treatment of cancer, viral infections and related diseases.
REFERENCES:
patent: 4939098 (1990-07-01), Suzuki et al.
patent: 4975278 (1990-12-01), Senter et al.
patent: 5213804 (1993-05-01), Martin et al.
patent: 5660827 (1997-08-01), Thorpe et al.
patent: 5677171 (1997-10-01), Hudziak et al.
patent: 5834599 (1998-11-01), Chang et al.
patent: 5863538 (1999-01-01), Thorpe et al.
patent: 6194430 (2001-02-01), Camden et al.
patent: 6300308 (2001-10-01), Schroit
patent: 6312694 (2001-11-01), Thorpe et al.
patent: 6333348 (2001-12-01), Vogel et al.
patent: 6406693 (2002-06-01), Thorpe et al.
patent: 6783760 (2004-08-01), Thorpe et al.
patent: 6806354 (2004-10-01), Schroit
patent: 6818213 (2004-11-01), Thorpe et al.
patent: 7067109 (2006-06-01), Thorpe et al.
patent: 7247303 (2007-07-01), Thorpe et al.
patent: 7422738 (2008-09-01), Thorpe et al.
patent: 2002/0025319 (2002-02-01), Brams
patent: 2003/0004097 (2003-01-01), Schroit
patent: 2003/0228625 (2003-12-01), Toh et al.
patent: 2004/0131610 (2004-07-01), Thorpe et al.
patent: 2004/0131621 (2004-07-01), Thorpe et al.
patent: 2004/0131622 (2004-07-01), Thorpe et al.
patent: 2004/0161429 (2004-08-01), Thorpe et al.
patent: 2004/0170620 (2004-09-01), Thorpe et al.
patent: 2004/0175378 (2004-09-01), Thorpe et al.
patent: 2004/0208868 (2004-10-01), Thorpe et al.
patent: 2004/0213779 (2004-10-01), Thorpe et al.
patent: 2004/0219155 (2004-11-01), Thorpe et al.
patent: 2004/0265367 (2004-12-01), Thorpe et al.
patent: 2005/0002941 (2005-01-01), Thorpe et al.
patent: 2005/0031620 (2005-02-01), Thorpe et al.
patent: 2005/0136059 (2005-06-01), Thorpe et al.
patent: WO 00/02584 (2000-01-01), None
patent: WO 00/02587 (2000-01-01), None
patent: WO 01/03735 (2001-01-01), None
patent: WO 01/68709 (2001-09-01), None
Stancovski, et al (PNAS, USA, 88:8691-8695, 1991).
Lewis, et al (Cancer Immunology Immunotherapy 37: 255-263,1993).
Strobel, et al (Gynecologic Oncology 73: 362-367, 1999).
Bowie et al, Science, 247:1306-1310, 1990, p. 1306, co1.2).
Gussow et al. (1991, Methods in Enzymology 203:99-121).
Rudikoff et al. (PNAS, USA, 1982, 79:1979).
Herbert, W.J. [and others] eds., Dictionary of Immunology, 4thed. London:Academic Press, 1995.
Umeda et al., 1989, J. of lmmunol. 143:2273-2279.
Rote et al., 1993, Clinical Immunology and Immunotherapy 66(3):193-200.
Paul, Fundamental Immunology, 3rd Edition, 1993, pp. 292-295, under the heading “Fv Structure and Diversity in Three Dimensions”.
Rudikoff et al (Proc. Natl. Acad. Sci. USA, 79(6):1979-1983, Mar. 1982).
Colman P. M. (Research in Immunology, 145:33-36, 1994).
Bendig M. M. (Methods: A Companion to Methods in Enzymology, 1995; 8:83-93).
MacCallum et al (J. Mol. Biol., 262, 732-745, 1996).
Casset et al (Biochemical and Biophysical Research Communications, 307:198-205, 2003, IDS).
Bevers et al (Clinical Immunology, 2004,112:150-160).
Luster et al (J Biological Chemistry, 2006, 281:29863-71, IDS).
Ran et al (Clinical Cancer Research, 2005, 11:1551-1562, IDS).
Casset et al., “A Peptide Mimetic of an Anti-CD4 Monoclonal Antibody by Rational Design”,Biochem. Biophys. Res. Commun., 307(1):198-205, 2003.
Hortobagyi, “Developments in Chemotherapy of Breast Cancer”,Cancer, 88(S12):3073-3079, 2000.
Balasubramanian and Schroit, “Aminophospholipid Asymmetry: A Matter of Life and Death”,Annu. Rev. Physiol., 65:701-734, 2003.
Beck et al., “Combination of a Monoclonal Anti-Phosphatidylserine Antibody with Gemcitabine Strongly Inhibits the Growth and Metastasis of Orthotopic Pancreatic Tumors in Mice”,Int. J. Cancer, 118:2639-2643, 2006.
Curti, “Physical Barriers to Drug Delivery in Tumors”,Crit. Rev. Oncol./Hematol., 14:29-39, 1993.
Goren et al., “Targeting of Stealth Liposomes in erbB-2 (HER/2) Receptor: In Vitro and In Vivo Studies”,Brit. J. Cancer, 74:1749-1756, 1996.
Gura, “Systems for Identifying New Drugs Are Often Faulty”,Science, 278:1041-1042, 1997.
Huang et al., “A Monoclonal Antibody that Binds Anionic Phospholipids on Tumor Blood Vessels Enhances the Antitumor Effect of Docetaxel on Human Breast Tumors in Mice”,Cancer Res., 65(10):4408-4416, 2005.
Ishida et al., A Combinatorial Approach to Producing Sterically Stabilized (Stealth) Immunoliposomal Drugs,FEBS Letters, 460:129-133, 1999.
Jain, “Barriers to Drug Delivery in Solid Tumors”,Scientific American., 271(1):58-65, 1994.
Janeway et al., “The Interaction of the Antibody Molecule with Specific Antigen”,Immunobiology, 5th ed., 7 pages, 2001.
Luster et al., “Plasma Protein Beta-2-glycoprotein 1 Mediates Interaction between the Anti-tumor Monoclonal Antibody 3G4 and Anionic Phospholipids on Endothelial Cells,”JBC Papers in Press, www.jbc.org/cgi/doi/10.1074/jbc., M605252200:1-20, 2006.
Maneta-Peyret et al., “Demonstration of High Specificity Antibodies Against Phosphatidylserine”,J. Immunol. Methods, 108:123-127, 1988.
Maruyama et al., “Lipid Composition is Important for Highly Efficient Target Binding and Retention of Immunoliposomes”,Proc. Natl. Acad. Sci. USA, 87:5744-5748, 1990.
Mellman, “Where Next for Cancer Immunotherapy?”,The Scientist, 20(1):47-56, 2006.
Ran and Thorpe, “Phosphatidylserine is a Marker of Tumor Vasculature and a Potential Target for Cancer Imaging and Therapy”,Int. J. Radiation Oncology Biol. Phys., 54(5):1479-1484, 2002.
Ran et al., “Antitumor Effects of a Monoclonal Antibody that Binds Anionic Phospholipids on the Surface of Tumor Blood Vessels in Mice”,Clin. Cancer Res., 11:1551-1562, 2005.
Ran et al., “Increased Exposure of Anionic Phospholipids on the Surface of the Tumor Blood Vessels”,Cancer Res.; 62:6132-6140, 2002.
Schneider-Gadicke and Riethmüller, “Prevention of Manifest Metastasis with Monoclonal Antibodies: A Novel Approach to Immunotherapy of Solid Tumours”,Eur. J. Cancer, 31A(7/8):1326-1330, 1995.
Thorpe et al., “Tumor Infarction: Immunoconjugates that Coagulate the Vasculature of Solid Tumors”,Proceeding of the American Association for Cancer Research, 36:488, Abstract #2910, Mar. 1995.
Contractual European Search Report for counterpart PCT Application, PCT/US03/21925, mailed Mar. 31, 2004.
European Search Report for Counterpart European Application No. 03764600.7, dated Dec. 27, 2004.
International Search Report for counterpart PCT Application, PCT/US03/21925, mailed Feb. 24, 2005.
Ahmad and Allen, “Antibody-Mediated Specific Binding and Cytotoxicity of Liposome-Entrapped Doxorubicin to Lung Cancer Cells in Vitro”,Cancer Res., 52:4817-4820, 1992.
De Pascalis et al., “Grafting of ‘Abbreviated’ Complementarity-Determining Regions Containing Specificity-Determining Residues Essential for Ligand Contact to Engineer a Less Immunogenic Humanized Monoclonal Antibody”,J. Immunol., 169:3076-3084, 2002.
Paul, “Fv Structure and Diversity in Three Dimensions”, InFundamental Immunology, Third Edition, 1993, pp. 292-295.
Ran Sophia
Thorpe Philip E.
Board of Regents , The University of Texas System
Fussey Shelley P. M.
Goddard Laura B
LandOfFree
Cancer treatment methods using selected immunoconjugates for... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cancer treatment methods using selected immunoconjugates for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cancer treatment methods using selected immunoconjugates for... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4125384