Surgery – Truss – Perineal
Patent
1976-01-22
1978-08-15
Howell, Kyle L.
Surgery
Truss
Perineal
128 11, 128399, 128404, 424 1, 424 85, 424147, A61B 1900, A61F 700, A61K 4300
Patent
active
041064887
ABSTRACT:
A treatment of cancer by the application of external electromagnetic energy capable of the generation of heat in intracellular particles to induce selective thermal death of cancer cells in living tissue. This process allows for the selective treatment of cancer cells in living tissue without damaging the normal cells.
The process comprises introducing minute particles into the interior of the cells of living tissue. These particles being injected intravenously while suspended in an appropriate solution are of a size generally having a diameter of approximately 1 micron or less and are of a material with properties, such as ferromagnetic, paramagnetic, or diamagnetic, so as to be inductively heated when subjected to a high frequency alternating electro-magnetic field. Introducing the particles as described, the patient is thereafter subjected to an alternating electromagnetic field to inductively heat the particles sufficiently to raise the temperature of the cells by an increment of 8.0.degree. - 9.5.degree. Centigrade thus killing the cancer cells without harming the normal cells. Further selectivity and increased affinity of the cancer cells for these particles may be achieved by incorporating specific radioisotopes or tumor specific antibodies bound to these particles.
These particles introduced intracellularly as described may be used as a method of delivering a chemotherapeutic agent primarily to the interior of the cancer cells by having the chemotherapeutic agent encapsulated within said particles and released at the proper time by application of the high frequency alternating electromagnetic field or by solubilizing the said particles within the cells.
REFERENCES:
patent: 3467076 (1969-09-01), Frisch et al.
patent: 3712291 (1973-01-01), Freeman
American Druggist, May 19, 1969, pp. 33 & 34.
Chemical Abstracts, vol. 73, 1970, #75201g.
Chemical Abstracts, vol. 72, 1970, #130460x.
Howell Kyle L.
Keegan Francis A.
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