Surgery – Instruments – Light application
Reexamination Certificate
1998-02-17
2001-09-04
Nasser, Robert L. (Department: 3736)
Surgery
Instruments
Light application
C606S016000
Reexamination Certificate
active
06283957
ABSTRACT:
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to a cancer therapeutic instrument for use in treatment for cancers and neoplasm, and more particularly a cancer therapeutic instrument for use in treatment for the cancers originated, for example, in an area which involves a great deal of difficulty in performing a resection operation, the organs and the like, for instance, pancreatic carcinoma, lung cancer, brain tumor, cancers originated in the brain stem area, and for the cancers which are unfavorable to be resected from the point of view of beauty and maintenance function, for example, breast cancer, head and neck cancer, tongue cancer and uterine cancer.
2. Description of the Related Art
Currently, cancer is one of the most terrible diseases which is left to mankind, and elucidation of its fundamental cause and therapy therefor are in a developing state.
As typical therapy, which is considered at present to be effective, surgical resection, radiation therapy and chemotherapy are well known and most frequently employed.
Among those therapeutic method, the surgical resection way is deemed to be most effective and is most frequently employed. On the other hand, for malignant tumors originated in the deep area of the body for which the surgical resection way cannot be employed, radiation therapy and chemotherapy are frequently used in combination. However, it often happens that both radiation therapy and chemotherapy involve strong adverse reaction, and the radiation therapy and chemotherapy are remarkably lower in complete cure rate in comparison with the surgical resection way and involve danger of relapses.
Recently, in view of the foregoing, there is hastened vigorously a study of cancer therapy according to physical therapy which involves no adverse reaction. As typical therapy, there are hyperthermia and phototherapy using a photosensitizer.
The hyperthermia is involved in a way such that a cancer cell is extinguished through heating and/or cooling thereof. It has been reported that keeping a cancer cell at a temperature, for example, higher by +5° C. than body temperature, which would cause merely relatively less damage to peripheral normal cells, throughout a definite time, alone may bring a great treatment effect.
On the other hand, the phototherapy is based on such a mechanism that irradiation with a specified wavelength of activation light on a cell absorbing a photosensitizer leads to an absorption of optical energy by the photosensitizer, so that activating oxygen, which will destroy the cell, emanates. This treatment utilizes the fact that an excretion ratio of the photosensitizer after injection thereof is extremely lower in a cancer cell in comparison with a normal cell, specifically, less than 1/3 (about 1/5).
The present invention is involved in the phototherapy, and thus the phototherapy will be described in detail hereinafter.
FIG. 9
is a graph showing a relation between time elapsed wherein a time point when an ATX-S10, which is one of photosensitizers, is injected into the body, is selected as a starting point and the relative concentrations of the ATX-S10 remaining in cells. The graph PN denotes the residual concentrations of the ATX-S10 within the normal cells; and the graph PC the residual concentrations of the ATX-S10 within the cancer cells.
When a certain standby time lapses (about 3 hours) after plenty of photosensitizer is injected into the affected part and its peripheral cells through a direct injection of the photosensitizer into the affected part, an intravenous injection and the like, the normal cells have discharged almost all the photosensitizer, whereas there appears such a state (light treatment feasible state) that almost all the photosensitizer stays in the cancer cells. In such a light treatment feasible state, irradiation with a specified wavelength of activation light leads to an emanation of activating oxygen, which will destroy the cells, within the cancer cells in which almost all the photosensitizer stays, while no activating oxygen almost emanates within the normal cells which have discharged almost all the photosensitizer, whereby the cancer cells are selectively extinguished.
Duration (the term of validity for light treatment) of the light treatment feasible state after an injection of the photosensitizer starts after 3 hours since injection of the photosensitizer and terminates after 14 hours with which the cancer cells have discharged almost all the photosensitizer. Incidentally,
FIG. 9
shows an ATX-S10 by way of example. The standby time after injection of the photosensitizer and the term of validity for light treatment will vary about one order of magnitude in accordance with the type of photosensitizer.
The gist of this treatment resides in the point that activation light is continuously projected onto the affected part as uniformly as possible during the term of validity for light treatment, and the amount of irradiation light is controlled in such a manner that cell-inside-concentrations of activating oxygen which causes cells to be extinguished is restricted to a very low value such that the death rate of the normal cells is in the permitted limit within the normal cells, whereas the cell-inside-concentrations of activating oxygen assumes a value such that the death rate of the cancer cells is nearly and 100% within the cancer cells.
To project the activation light onto the affected part, hitherto, an optical fiber is directly inserted into the affected part and activation light is transmitted through the optical fiber. However, according to this scheme:
(a) Since the optical fiber cannot be moved during the treatment, irradiation area or the therapeutic area is extremely limited;
(b) To project light from the tip of the optical fiber in all directions, it is necessary to cut the tip of the optical fiber, for example, in a cone shape. Processing for such an optical fiber is difficult and then the optical fiber is very expensive;
(c) To perform the treatment repeatedly, it is necessary to repeat insertion of the optical fiber whenever the treatment is performed. It is a great burden to both a patient and a doctor;
(d) Since the therapeutic area is narrow, it is difficult to cure completely large cancers and tumors; and
(e) There are needs of sterilization of the optical fiber before use and re-sterilization of the optical fiber after each use or solid waste disposal. Usually, it is needed to provide an optical fiber having a length not less than 1 m, and the optical fiber is of a compound material. Consequently, the sterilization and the solid waste disposal are troublesome and thus the optical fiber is poor in operational efficiency.
SUMMARY OF THE INVENTION
In view of the foregoing, it is therefore an object of the present invention to provide a cancer therapeutic instrument capable of obtaining a great effect in light treatment through irradiation with activation light on the affected part over a wide range. The cancer therapeutic instrument is excellent in operational efficiency and is inexpensive.
To achieve the above-mentioned object of the present invention, according to the present invention, there is provided the first cancer therapeutic instrument comprising:
a catheter type of insertion member having a tube of which a tip is closed, a tip end of the tube being adapted to be inserted into a subject to be treated, and an optical fiber of which a tip end is adapted to be disposed slidably inside said tube;
a light source for emitting a predetermined activation light, said light source being arranged to introduce the activation light into said optical fiber so that the activation light travels within said optical fiber and emanates from a tip of said optical fiber at an end thereof in which said optical fiber is disposed inside said tube; and
a driving mechanism for driving said optical fiber in such a manner that said optical fiber disposed inside said tube performs at least one movement selected from the group including reciprocation in a longitudinal direction of sai
Hashimoto Yasuo
Hirano Toru
Yamaguchi Noboru
Hamamatsu Photonics K.K.
Kubovcik & Kubovcik
Nasser Robert L.
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