Cancer susceptibility test

Details Cancer susceptibility test Cancer susceptibility test

1984-12-28

1988-04-05

Marantz, Sidney

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 26, 435 29, 43524023, 436813, C12Q 102, C12Q 132

Patent

active

047358955

ABSTRACT:
The present invention relates to an improved viral transformation
eodifferentiation assay for determining predisposition to cancer. The invention is based on the association between retroviral transformation
eodifferentiation and a predisposition to cancer. The level of lipogenic enzymes is measured in cultured human fibroblast cells after transformation
eodifferentiation with Kirsten murine sarcoma virus in the presence of glucocorticosteroids to monitor the extent of conversion of the human skin fibroblasts to fully mature adipocytes.

REFERENCES:
patent: 4529693 (1985-07-01), Smith
patent: 4532220 (1985-07-01), Lavi
patent: 4535058 (1985-08-01), Weinberg
patent: 4582787 (1986-04-01), Frankel
Chemical Abstracts, 100:63293b (1984).
Rhim, J. S., Proc. Soc. Exp. Biol. Med., 174(2), 217-223 (1983).
Wise, L. S. et al., J. Biol. Chem. 254(2), 273-275 (1979).
Pfeffer and Kopelovich, 1977, Cell 10:313-320.

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