Cancer screening method

Details Cancer screening method Cancer screening method

2009-08-18

2011-11-01

Martinell, James (Department: 1634)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S006180

Reexamination Certificate

active

08048634

ABSTRACT:
A method for screening cancer comprises the following steps: (1) providing a test specimen; (2) detecting the methylation rate of the CpG sequence in at least one target gene of the test specimen, wherein the target genes is consisted of PTPRR, ZNF582, PDE8B and DBC1; and (3) determining whether there is cancer or cancerous pathological change in the specimen based on the methylation rate in the target gene.

REFERENCES:
patent: 2008/0311570 (2008-12-01), Lai
patent: 96102422 (2008-08-01), None
Gronbaek et al, Modern Pathology 21 (5), 632 (2008).
Izumi et al, Human Molecular Genetics 14 (8), 997 (2005).
Peter C. Scacheri, Gregory E. Crawford, and Sean Davis; Article: Statistics for ChIP-chip and DNase Hypersensitivity Experiments on NimbleGen Arrays; Methods in Enzymology, vol. 411 pp. 270-282. Elsevier Inc. 2006.
Po-Hsuan Su, et al.; Presentation Title: Epigenomic analysis of DNMT3B-mediated cervical cancer invasion by methylated DNA immunoprecipitation identifies PTPRR as a metastasis suppressor gene; AACR Annual Meeting Apr. 22, 2009.

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