Cancer-related antigen-specific human immunoglobulins and human/

Details Cancer-related antigen-specific human immunoglobulins and human/ Cancer-related antigen-specific human immunoglobulins and human/

1988-05-20

1992-03-03

Mars, Howard T.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 702, 435 7021, 4351722, 43524021, 530386, 53038815, 5303888, 530861, 935 99, 935100, C12N 500

Patent

active

050932616

ABSTRACT:
A new human/human fused cell clone derived from human B cells having the ability to produce immunoglobulins and human B cells substantially lacking the ability to produce immunoglobulins, antigen-specific human immunoglobulins produced by the human/human fused cell clone, and a method of producing the human immunoglobulins. More specifically, a human/human hybridoma having the ability to produce antigen-specific human immunoglobulins, which is a human/human fused cell strain derived from human B cells of a human patient with liver cancer and a subclone of a human lymphoblast cell strain; and antigen-specific human immunoglobulins produced by the human/human fused cell strain.

REFERENCES:
patent: 4693975 (1987-09-01), Kozbor et al.
patent: 4761377 (1988-08-01), Glassy et al.
patent: 4942123 (1990-07-01), Lee et al.
patent: 5618577 (1986-10-01), Handley et al.
Olsson et al. "Human-Human Hybridoma . . . ", Human Hybridomas & Monoclonal Antibodies pp. 227-242, 1985 (Plemum Press).

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