Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1994-01-24
1998-06-02
Spiegel, Carol A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 79, 435 792, 435975, 435 6, 436518, 436 64, 530324, 530350, 5303888, 5303897, 536 231, 536 243, G01N 33574
Patent
active
057597910
ABSTRACT:
A method of determining the prognosis of a solid tumor is provided, in which a sample from a patient bearing a tumor is assayed for the presence of a protein which is immunologically cross-reactive with the hr gene product, but not with haptoglobin 1 or haptoglobin 2. Also provided is a method for preparing antibodies specific for this diagnostic marker which correlates with early relapse and metastasis of breast and other cancers. The marker can be detected using immunological methods employing antibodies specific for Hpr protein and not cross-reactive with haptoglobins 1 or 2.
REFERENCES:
D. Chalbos et al. "Expression of the Progestin-Induced Fatty Acid Synthetase in Benign Mastopathies and Breast Cancer as Measured by RNA In Situ Hybridization," JNCI 82(7):602-606, 1990.
H. Fawcett et al., "Identification of the products of the haptoglobin-related gene," Biochem. Biophys. Acta 1048 (2/3):187-193, 1990.
F. Kuhajda et al, "Haptoglobin-Related Protein (Hpr) Epitopes in Breast Cancer as a Predictor of Recurrence of the Disease," New Engl. J. Med. 321(10):636-641, 1989.
F. Kuhajda et al., "Expression of Haptoglobin-Related Protein and its Potential Role as a Tumor Antigen," PNAS 86(4):1188-1192, 1989.
N. Maeda, "Nucelotide Sequence of the Haptoglobin and Haptoglobin-related Gene Pair," J. Biol. Chem. 260(11):6698-6709, 1985.
Kuhajda Francis P.
Pasternack Gary R.
Posorske Laurence H.
Spiegel Carol A.
The Johns Hopkins University
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