Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Patent
1995-06-05
1999-01-26
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
530300, 530350, 530806, 530850, 530851, 435 691, 436 63, 436 64, 436 86, C07K 1400
Patent
active
058640118
ABSTRACT:
A method of determining the prognosis of a solid tumor is provided, in which a sample from a patient bearing a tumor is assayed for the presence of a protein which is immunologically cross-reactive with the hpr gene product, but not with haptoglobin 1 or haptoglobin 2. Also provided is a method for preparing antibodies specific for this diagnostic marker which correlates with early relapse and metastasis of breast and other cancers. The marker can be detected using immunological methods employing antibodies specific for Hpr protein and not cross-reactive with haptoglobins 1 or 2.
REFERENCES:
patent: 3535309 (1970-10-01), Hata et al.
patent: 3630846 (1971-12-01), Hata et al.
patent: 3897428 (1975-07-01), Omura et al.
patent: 3909361 (1975-09-01), Hata et al.
patent: 4000164 (1976-12-01), Parker
patent: 4011334 (1977-03-01), Parker
patent: 4032647 (1977-06-01), Parker
patent: 4110351 (1978-08-01), Parker
patent: 4328246 (1982-05-01), Gold
patent: 4602099 (1986-07-01), Parker
patent: 4738984 (1988-04-01), Parker
patent: 4789630 (1988-12-01), Block et al.
patent: 4946774 (1990-08-01), Oh
patent: 4968494 (1990-11-01), Claremon et al.
patent: 5143907 (1992-09-01), Spielvogel
patent: 5185149 (1993-02-01), Baldwin et al.
patent: 5188830 (1993-02-01), Atkinson et al.
patent: 5190969 (1993-03-01), Blumenstein et al.
Bacchi, et al., "Effects of Some Antitumor Agents on Growth and Glycolytic Enzymes of the Flagellate Crithidia," Journal of Bacteriology. 98:23-28 (1969).
Furnica, et al., "Mecanismes Biochmiques Impliques Dans La Sensibilisation Des Organismes Vivants Par Des Agents Chimiques A L'Action Des Radiations et Des Cytostatiques," Rev. Roum. Bioshim., 8:117-122 (1971).
Vivants Par Des Agents Chimiques A L'Action Des Radiations et Des Cytosatiques, Rev. Roum. Biochim., 8:117-122 (1971).
Omura, et al., "Relationship Between the Structures of Fatty Acid Amide Derivatives and Their Antimicrobial Activities," Antimicrobial Agents and Chemotherapy, 6:207-215 (1974).
Nery et al., "Isolation and Partial Characterization of Macromolecular Urinary Aggregates Containing Carcinoembryonic Antigen-Like Activity," British Jour. of Cancer (1974) 413-424.
Schroering, et al., "Fatty Acid Synthetiase In Chemically Induced Mammary Carninomas", Res. Communications In Chem. Path. and Pharmocology, (1974) 9:775-778.
Lin, et al., "Fatty Acid Synthetase from a Mouse Mammary Adenocarcinoma", Cancer Research, (1975) 35:3094-3099.
Abraham, et al., "Lipid and Lipogenesis in a Murine Mammary Neoplastic System", in Control Mechanisms in Cancer, Criss, et al eds., pp. 363-378, Raven Press, NY (1976).
Omura, Satoshi, "The Antibiotic Cerulenin, a Novel Tool for Biochemistry as an Inhibitor of Fatty Acid Synthesis," Bacteriological Reviews, 40:681-697 (1976).
Pitot, et al., "Contribution of the Morris Hepatomas to the Biochemistry of Cancer-Establishment of the Phenotypic Heterogeneity of Neoplasms In Vivo", Progress In Cancer Res. and Therapy, (1976) 1:21-37.
Partida, et al., "Comparative Effects of Diphenylglioxal and its Superoxide on Experimental Tumors," Arch. de Farmacol. y Toxicol., 111:231-240 (1977).
Javid et al., "Human Haptoglobins," Curr. Topics in Hematology, (1978), 1:151-192.
Cooper et al., "Acute Phase Reactant Proteins in Cancer," Advances in Cancer Research, (1979), 30:1-44.
Ahmad, et al., "Increase in Fatty Acid Synthetase Content of 3T3-L Cells Undergoing Spontaneuos and Chemically Induced Differentiation to Adipocytes", Biochem. J. (1979) 182:509-514.
O'Brien et al., "Qualitative Analysis of Proteinuria Associated with Bladder Cancer," Investigative Urology, (1979), 17:28-32.
Folkersen et al., "Affinity Chromatographic Purification of a New High Molecular Weight Pregnancy Specific Protein-SP-4," Carcino-Embryonic Proteins (1979), 2:503-508.
Davis et al., "Reactions wiht Simple Haptens," Microbiology, 3rd Ed., Harper & Row, pp. 298-306 (1980).
Sutcliffe et al., "Studies on Human Pregnancy-Associated Plasma Protein A," Biochem. Jour. (1980), 191:799-809.
Smith, et al., "Thioesterase II, a New Marker Enzyme for Human Cells of Breast Epithelial Origin," JNCI, 73:323-328 (1981).
Thompson, et al., "Purification and Properties Of Fatty Acid Synthetase From A Human Breast Cell LIne", Biochim. Biophys. Acta, 662:125-130 (1981).
Omura, Satoshi, Chapter 39 "Cerulenin" in Methods in Enzymology, 72:520-532, 1981.
Ahmad, et al., "Inactivation of Rat Mammary Gland Fatty Acid Synthetase By S-(4-bromo-2,3-dioxobutyl)-Coenzyme", Fed. Proc. (1981) 40:1794 Abstract 1463.
Thompson, et al., "Lack of Coordinated Regulation Of Lipogenic Enzymes In A Human Breast Cell Line SKBr3", Biochim. Biophys. Acta, 712:217-220 (1982).
Clements, et al., "Irreversible Inhibition of Fatty Acid Synthase from Rat Mammary Gland with S-(4-bromo-2,3-dioxobutyl)-CoA", Biochem. J. (1982) 207:291-296.
Ahmad, et al., "Studies on Acetyl-CoA Carboxylase and Fatty Acid Synthase from Rat Mammary Gland and Mammary Tumors", Biochem. J. (1982) 208:443-452.
Baseler et al., "Purification of Haptoglobin and Its Effects on Lymphocyte and Alveolar Macrophage Responses," Inflammation, (1983), 7:387-400.
Haram et al., "Serum Protein Pattern in Normal Pregnancy with Special Reference to Acute-Phase Reactants," British Jour. of Obstetrics and Gynaecology (1983), 90:139-145.
Kuhajada et al., "The Distribution of Carcinoembryonic Antigen in Breast Carcinoma," Cancer (1983), 52:1257-1264.
Mendoza, et al., "Thermal Regulation of Membrane Fluidity in Escherichia coli," J. Biol. Chem., 258:2098-2101 (1983).
Spiegelman, et al., "Fibronectin Modulation of Cell Shape and Lipogenic Gene Expression in 3T2-Adipocytes", Cell (1983) 35:657-666.
Bischof, "Placental Proteins," Contributions to Gynecology and Obstetrics (1984), 12:1-5 and 41-74.
Maeda et al., "Duplication Within the Haptoglobin Hp.sup.2 Gene," Nature, (1984),309:131-135.
Schindler et al., "Histochemical Localization of Pregnancy-Associated Plasma a in Fetal, Infant. and Adult Organs and Comparison Between Antisers," Gynecol. Obstet. Invest. (1984), 18:88-94.
Bischof, "Placenta Proteins," Contributions to Gynecology and Obstetrics (1984), 12:46-55.
Kuhajda et al., "Pregnancy-Specific Beta-1 Glycoprotein (SP-1) in Breast Carcinoma," Cancer (1984), 54:1392-1396.
Maeda, "Nucleotide Sequence of th Haptoglobin and Haptoglobin-Related Gene Pair," Jour. of Biol. Chem., (1985), 260:6698-6709.
Bensi et al., "Structure ad Expression of the Human Haptoglobin Locus," The EMBO Journal, (1985) 4:119-126.
Kuhajda et al., "Pregnancy-Associated Plasma Protein A:A Clinically Significant Predictor of Early Recurrence in Stage I Breast Carcinom is Independent of Estrogen Receptor Status", Am. J. Pathol. (1985), 121:342-348.
Kuhajda et al., "Pregnancy-Associated Plasma Protein A:A Cliniclly Significant Predictor of Early Recurrence in State II Breast Carcinoma," Hum. Pathol. (1985), 16:228-235.
Ceriani, et al., "Imunohistochemical Studies In Breast Cancer Using Monoclonal Antibodies Against Breast Epithelial Cell Components and With lectins", Devel. Oncol., (1985) 34:233-63.
Hait, et al., "Inhibition of Growth of Leukemic Cells by Inhibitors Of Calmodulin: Phenolthiazines and Metittin," Cancer Chemother. Pharmacol., 14:202-205 (1985).
Pawlak, et al., "Evaluation of Thioesterase II as a Serum Marker for Rat Mammary Cancer," Cancer Research, 46:4712-4719 (1986).
Mowles et al., "A Two-Site Immunoradiometric Assay for Human Pregnancy-Associated Plasma Protein A (PAPP-A) Using Monoclonal Antibodies", Journal of Immunological Methods, (1986) 95:129-133.
Maeda et l., "Polymorphisms in the Human Haptoglobin Gene Cluster: Chromosomes with Multiple Haptoglobin-Related (Hpr) Genes," Proc. Natl. Acad. Sci. USA (1986), 83:7395 7399.
Chemnitz et al., "Comparison of Differenct Antibody Preparations Against Pregnancy-Associated Plasma Protein-A (PAPP-A) for Use in Localization and Immunoassay Studies," Br. Jour. of Obstetrics and Gynaecology (1986), 93:916-923.
Fujii, et al., "Effect of Cerulenin, an Inhibitor of Fatty Acid Synthesis, on the Immune Cytolysis of Tumor Cells", Jap. Jap. J. Exp. Med., 56:99-106 (1986).
Chalbos, et al., "Cloning o
Kuhajda Francis P.
Pasternack Gary R.
Celsa Bennett
The Johns Hopkins University
Tsang Cecilia J.
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