Cancer inhibitory peptides

Details Cancer inhibitory peptides Cancer inhibitory peptides

1994-11-10

1997-02-04

Woodward, Michael P.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

4 to 5 amino acid residues in defined sequence

530331, C07K 500, C07K 700, C07K 1700, A61K 3800

Patent

active

055999026

ABSTRACT:
The sea hare Dolabella auricularia has yielded many structurally distinct ptides which possess antineoplastic activity. Presently the compound denominated "dolastatin 10" represents the most important of such peptides because of its demonstrated potential as an anticancer drug.
The present invention relates to the systematic creation of seven unique pentapeptides by selectively coupling a tripeptide-trifluoroacetate salt with a preselected dipeptide trifluoroacetate salt which provide active molecules capable of emulating the measured therapeutic effect of dolastatin 10.

REFERENCES:
patent: 5502032 (1996-03-01), Haupt et al.
patent: 5504191 (1996-04-01), Pettit et al.

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