Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1995-06-06
1997-10-07
Chambers, Jasemine C.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
435375, 4353201, 435 691, 4351723, 435 6952, 935 62, 935 71, 935 33, 424 9321, 4242771, A61K 4800, A61K 3576, C12N 500
Patent
active
056744862
ABSTRACT:
A novel method of tumor immunotherapy is described comprising the genetic modification of cells resulting in the secretion of cytokine gene products to stimulate a patient's immune response to tumor antigens. In one embodiment, autologous fibroblasts genetically modified to secrete at least one cytokine gene product are utilized to immunize the patient in a formulation with tumor antigens at a site other than an active tumor site. In another embodiment, cells genetically modified to express at least one tumor antigen gene product and to secrete at least one cytokine gene product are utilized in a formulation to immunize the patient at a site other than an active tumor site.
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Butler et al, Immunopharmacology & Immunotoxicity 11(2&3) 445-487, 1989.
Lanzavecchia A. Science 260:937-944, 1993.
Friedmann Theodore
Gage Fred H.
Royston Ivor
Sobol Robert E.
Chambers Jasemine C.
Hauda Karen M.
San Diego Regional Cancer Center
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