Cancer drug screen based on cell cycle upcoupling

Chemistry: analytical and immunological testing – Process or composition for determination of physical state... – Corrosion resistance or power

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 29, C12Q 100

Patent

active

058798897

ABSTRACT:
Checkpoint gene-defective human cells are useful for screening potential anti-tumor agents. Potential therapeutic agents are screened for the ability to cause DNA accumulation or cell death in a checkpoint gene-defective human cell.

REFERENCES:
Little et el. The Journal of Biological Chemistry. vol. 270, No. 19, pp. 11033-11036, May 12, 1995.
Girinsky et al. Cancer Research. vol. 55, pp. 3726-3731, Sep. 1, 1995.
Vidal et al. Melanoma Research. vol. 5, pp. 243-250, Aug. 1995.
Waldman et al. Cancer Research, vol. 55, pp. 5187-5190 (Nov. 15, 1995).
Brugarolas, "Radiation-induced Cell Cycle Arrest Compromised By p. 21 Deficiency," Nature 377:522-557 (1995).
Deng, "Mice Lacking p.21.sup.CIP1/WAF1 Undergo Normal Development, But Are Defective in G1 Checkpoint Control," Cell, 82:675-684(1959).
Gao, "Somatic Mutations of the WAF1/CIP1 Gene in Primary Prostate Cancer," Oncogene, 11, 1395-1398(1995).
Gorczyca, "Detection of DNA Strand Breaks in Individual Apoptotic Cells by the in Situ Terminal Deoxynucleotidyl Transferase and Nick Translation Assays," Cancer Research, 53:1945-1951 (1993).
Hotz, Changes in Nuclear Chromating Related in Apoptosis or Necrosis Induced by the DNA Topoisomerase II Inhibitor Fostriecin in MOLT-4 and HL-60 Cells are Revealed by Altered DNA Sensitivity to Denaturation, Exp. Cell Research, 201:184-191 (1992).
Hunter, Cyclins and CancerII: Cyclin D and CDK Inhibitors Come of Age, Cell, 79:573-582 (1994).
Kung, "Cell Line-Specific Differences in the Control of Cell Cycle Progression in the Absence of Mitosis," Cell Biology, 87:9553-9557.
Sheer, "Inhibitors of Mammalian G, Cyclin-Dependent Kinaser," Genes & Development, 9:1149-1163 (1995).
Swat, "Detection of Apoptosis of Immature CD4+8+Thymocytes by Flow Cytometry," J. Immunol, Meth. 137:79-87 (1991).
Woods, "Taxol-Induced Mitotic Block Triggers Rapid Onset of a p 53-Independent Apoptotic Pathway," Molecular Medicine, 1:506-526 (1995).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Cancer drug screen based on cell cycle upcoupling does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cancer drug screen based on cell cycle upcoupling, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cancer drug screen based on cell cycle upcoupling will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1319636

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.