Cancer diagnosis prognosis and therapy based on mutation of rece

Details Cancer diagnosis prognosis and therapy based on mutation of rece Cancer diagnosis prognosis and therapy based on mutation of rece

1995-05-22

1999-02-02

Allen, Marianne P.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 71, 435 72, 435 721, 435 723, 436503, 436811, C12N 1500, G01N 33567

Patent

active

058663231

ABSTRACT:
This invention is based on the discovery that the type II TGF-.beta. receptor (RII) is a cancer suppressor gene which is genetically inactivated (mutated) in approximately 25% of colon cancers, including nearly all colon cancers of the class identified as mutator/microsatellite instability/RER. Methods are provided for detecting inactivation of RII for use in cancer diagnosis or prognosis.

REFERENCES:
patent: 4399216 (1983-08-01), Axel et al.
patent: 4446128 (1984-05-01), Baschang et al.
patent: 4920209 (1990-04-01), Davis et al.
patent: 5166059 (1992-11-01), Pastan et al.
Hasegawa, et al., "Characterization of a Human Hepatoma Cell Line with Acquired Resistance to Growth Inhibition by Transforming Growth Factor Beta 1 (TGF-.beta.1)", In-Vitro Cell Dev. Biol., vol. 31a, No. 1, Jan. 1995, pp. 55-61.
Brand, et al., "A dominant-negative Receptor for Type .beta. Transforming Growth Factors Created by Deletion of the Kinase Domain:", J. Biol. Chem. vol. 266, No. 14, May 1991, pp. 9018-9112.
Parsons, et al., "Microsatellite Instability and Mutations of the Transforming Growth Factor .beta. Type II Receptor Gene in Colorectal Cancer", Cancer Res., vol. 55, Dec. 1995, pp. 5548-5550.
Myeroff, et al., "A Transforming Growth Factor .beta. Receptor Type II Gene Mutation Common in Colon and Gastric but Rare in Endometrial Cancers with Microsatellite Instability", Cancer Res., vol. 55, Dec. 1995, pp. 5545-5547.
Wang, et al., "Demonstration That Mutation of the Type II Transforming Growth Factor .beta. Receptor Inactivates its Tumor Suppressor Activity in Replication Error-positive Colon Carcinoma Cells", J. Biol. Chem., vol. 270, No. 37, Sep. 1995, pp. 22044-22049.
Brand, et al., :Inactive Type II and Type I Receptors for TGF.beta. Are Dominant Inhibitors of TGF.beta.-dependent Transcription, J. Biol, Chem., vol. 270, No. 14, Apr. 1995, pp. 8274-8284.
Altered Expression of Transmorming Growth Factor-.alpha. and Transforming Growth Factor-.beta. Autocrine Loops in Cancer Cells:, M.G. Brattain et al., Advanced in Molecular and Cell Biology, vol. 7, pp. 35-59, 1993.
"Inactivation of the Type II TGF-.beta. Receptor in Colon Cancer Cells with Microsatellite Instability", S. Markowitz et al., Science, vol. 268, Jun. 1995.
"DNA Repair Defect Tied to Mutated TGF-.beta. Receptor Gene", Jean Marx, Science, vol. 268, pp. 1276-1277, Jun. 1995.
"Loss of Receptors for Transforming Growth Factor .beta. in Human T-cell Malignancies", M. Kadin et al, Pro. Natl. Acad. Sci., USA, vol. 91, pp. 6002-6006, Jun. 1994.
"Clues to the Pathogenesis of Familial Colorectal Cancer", Lauri A. Aaltonen, et al, Science, vol. 260, pp. 812-815, May 1993.
"Transforming Growth Factor .beta..sub.1 Can Induce Estrogen-Independent Tumorigenicity of Human Breast Cancer Cells in Athymic Mice.sup.1 ", Carlos L. Arteaga, et al, Cell Growth & Differentiation, vol. 4, pp. 193-201, Mar. 1993.
"TCF-.beta. Expression in the Human Colon: Differential Immunostaining Along Crypt Epithelium", A. Avery et al, Brit. J. Cancer, vol. 68, p. 137.
"High-Resolution in Situ Hybridization Histochemistry", Frank Baldino, Jr., et al, Methods in Enzymology, vol. 168, pp. 761-777.
"A Transforming Growth Factor .beta. Type 1 Receptor That Signals to Activate Gene Expression", Craig H. Bassing, Science, vol. 263, pp. 87-89, Jan. 1994.
".beta..sub.2 -Microglobulin Gene Mutations: A Study of Established Colorectal Cell Lines and Fresh Tumors", D.C. Bicknell, et al, Proc. Natl. Acad. Sci. USA, vol. 91, pp. 4751-4755, May 1994.
"Transforming Growth Factor-.beta. Inhibition of Epithelial Cell Proliferation Linked to the Expression of a 53-kDa Membrane Receptor", Frederick T. Boyd et al, The Journal of Biological Chemistry, vol. 264, No. 4, pp. 2272-2278, Feb. 1989.
"Growth Factor Balance and Tumor Progression", Michael G. Brattain, et al, Current Opinion in Oncology, vol. 6, pp. 77-81, 1994.
"Mutation in the DNA Mismatch Repair Gene Homologue hMLH 1 is Associated with Hereditary Non-Polyposis Colon Cancer", C. Bronner et al, Nature, vol. 368, pp. 258-261, Mar. 1994.
"Immune Response to p53 is Dependent Upon p53/HSP70 Complexes in Breast Cancers", Andrew M. Davidoff, Proc. Natl. Acad. Sci. USA, vol. 89, pp. 3439-3442, Apr. 1992.
"Total Synthesis of a Human Leukocyte Interferon Gene", Michael D. Edge, et al, Nature, vol. 292, pp. 756-762, Aug. 1981.
"Nonradioactive Methods of in Situ Hybridization: Visualization of Neuroendocrine mRNA", P.C. Emson et al, Methods of Enzymology, vol. 168, pp. 753-760.
"Increased Mutation Rate at the hprt Locus Accompanies Microsatellite Instability in Colon Cancer", James R. Eshleman, Oncogene, vol. 10, pp. 33-37, 1995.
"Microsatellite Instability in Inherited and Sporadic Neoplasms", James R. Eshleman, Current Opinion in Oncology, vol. 7, pp. 83-89, 1995.
"Development of Resistance Mechanism to the Growth-Inhibitory Effects of Transforming Growth Factor-.beta. During Tumor Progression", Jorge Filmus, et al, Current Opinion in Oncology, vol. 5, pp. 123-129, 1993.
"The Human Mutator Gene Homolog MSH2 and Its Association with Hereditary Nonpolyposis Colon Cancer", Richard Fishel, et al, Cell, vol. 75, pp. 1027-1038, Dec. 1993.
"Detection of p53 Gene Mutations in Rat Hepatocellular Carcinoma Cell Lines by Denaturing Gradient Gel Electrophoresis", Ikue Fukuda, et al, Molecular Carcinogensis, vol. 7, pp. 257-262, 1993.
"Inhibition of Growth by Transforming Growth Factor-.beta. following Fusion of Two Nonresponsive Human Carcinoma Cell Lines", Andrew G. Geiser, et al, The Journal of Biological Chemistry, vol. 267, No. 4, pp. 2588-2593, Feb. 1992.
"Loss of Expression of Transforming Growth Factor .beta. in Skin and Skin Tumors is Associated with Hyperproliferation and a High Risk for Malignant Conversion", Adam B. Glick, et al, Pro. Natl. Acad. Sci. USA, vol. 90, pp. 6076-6080, Jul. 1993.
"Differential Sensitivity of Subclasses of Human Colon Carcinoma Cell Lines to the Growth Inhibitory Effects of Transforming Growth Factor-.beta.1", Naseema S. Hoosein, et al, Experimental Cell Research, vol. 181, pp. 442-453, 1989.
"Ubiquitous Somatic Mutations in Simple Repeated Sequences Reveal a New Mechanism for Colonic Carcinogensis", Yurij Ionov, et al, Nature, vol. 363, pp. 558-561, Jun. 1993.
"Detection of Point Mutations by SSCP of PCR-Amplified DNA After Endonuclease Digestion", Iwanhana, et al, Biotechniques, vol. 12, No. 1, 64-66, 1992.
"Chemical Synthesis of Biologically Active Gene for Human Immune Interferon-.gamma.", Ernest Jay, et al, The Journal of Biological Chemistry, vol. 259, No. 10, pp. 6311-6317, May 1984.
"Clinical and Pathological Characteristics of Sporadic Colorectal Carcinomas with DNA Replication Errors in Microsatellite Sequences", Hoguen Kim, et al, American Journal of Pathology, vol. 145, pp. 148-156, Jul. 1964.
"Absence of TGF-.beta. Receptors and Growth Inhibitory Responses in Retinoblastoma Cells", Adi Kimchi, et al, Science, vol. 240, pp. 196-199.
"Derivation of Specific Antibody-Producing Tissue Culture and Tumor Lines by Cell Fusion", G. Kohler et al, Eur. J. Immunol., vol. 6, pp. 511-519, 1976.
"Activation of ras Oncogenes Preceding the Onset of Neoplasia", Ramesh Kumar, et al, Science, vol. 248, pp. 1101-1104, Jun. 1990.
"Activation of H-ras Oncogenes in Preneoplastic Mouse Mammary Tissues", Ramesh Kumar, et al, Oncogene, vol. 5, pp. 1271-1277.
"Clinical Implications of the p53 Tumor-Suppressor Gene", Curtis C. Harris, et al, The New England Journal of Medicine, vol. 329, No. 18, pp. 1318-1327, Oct. 1993.
"Loss of Transforming Growth Factor .beta..sub.1 and Its Effects on the Growth of EBV-Transformed Human B Cells", Ashok Kumar, et al, The Journal of Immunology, vol. 147, No. 3, pp. 998-1006.
"Slippery DNA and Diseases", Thomas A. Kunkel, Nature, vol. 365, pp. 207-208, Sep. 1993.
"Concomitant Loss of Transforming Growth Factor (TGF)-.beta. Receptor Types I and II in TGF-.beta.-resistant Cell Mutants Implicates Both Receptor Types in Signal Transduction", Marikki Laiho, et al, The Journal of Biological Chemistry, vol. 265, No. 30, pp. 18518-18524, Oct. 1990.
"Accumulation of Multiple Mutations in Tumour Suppresso

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