Cancer associated polypeptide antigen, process for its preparati

Details Cancer associated polypeptide antigen, process for its preparati Cancer associated polypeptide antigen, process for its preparati

1973-06-25

1976-06-01

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

23230B, 424 12, 424 85, 424 88, 424177, 260121, C07G 700

Patent

active

039608271

ABSTRACT:
A process for the isolation of cancer associated polypeptide antigen mainly by several steps of gel filtration and pH-gradient elution; a cancer associated polypeptide antigen based on a single peptide chain and denaturating irreversibly at pHs exceeding about 4.5; a composition comprising such antigen and a stabilizing amount of albumen in admixture therewith and a method of making such composition; a diagnostic composition comprising a particulate material labelled with albumen-stabilized antigen; process for preparing antibodies monospecific with regard to the cancer associated polypeptide antigen comprising preparing an oil emulsion, wherein an acid aqueous solution of the polypeptide is enclosed phase protected by a surrounding oil phase; a cancer diagnosis method based on determining the presence of cancer associated polypeptide antigen in a living animal body under examination; and composition useful as an immunizing agent containing as an active ingredient the cancer associated polypeptide antigen.

REFERENCES:
patent: 3823126 (1974-07-01), Bjorklund
Int. Arch. Allergy, 12=pp. 241-261, (1958), Bjorklund et al.
Int. Arch. Allergy, 36=pp. 191-203 (1969), Bjorklund.
Analytical Biochemistry, vol. 41, No. 1, May 24, 1971.

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