Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1979-03-30
1980-07-08
Fagelson, Anna P.
Drug, bio-affecting and body treating compositions
Lymphokine
260112R, 260112B, 260121, 424 8, 424 12, 424 85, 424 95, 424177, A61K 3700, A61K 3900, C07G 700, G01N 3100
Patent
active
042117666
ABSTRACT:
A process for the isolation of cancer associated polypeptide antigen mainly by several steps of gel filtration and pH-gradient elution; a cancer associated polypeptide antigen based on a single peptide chain and denaturating irreversibly at pHs exceeding about 4.5; a composition comprising such antigen and a stabilizing amount of albumen in admixture therewith and a method of making such composition; a diagnostic composition comprising a particulate material labelled with albumen-stabilized antigen; process for preparing antibodies monospecific with regard to the cancer associated polypeptide antigen comprising preparing an oil emulsion, wherein an acid aqueous solution of the polypeptide is enclosed phase protected by a surrounding oil phase; a cancer diagnosis method based on determining the presence of cancer associated polypeptide antigen in a living animal body under examination; and composition useful as an immunizing agent containing as an active ingredient the cancer associated polypeptide antigen.
REFERENCES:
Bjorklund, Immuno. Tech. for Detection of Cancer, Bonniers, Stockholm, Sweden, 1973, pp. 193-203, 237-247.
Bjorklund, Int. Arch. Allergy, vol. 8, 1956, pp. 179-192.
Bjorklund, Int. Arch. Allergy, vol. 36, 1969, pp. 191-203.
Bjorklund, reprint Protides of the Biol. Fluids, 24th Colloq. Bruges, 1975, Pergamon Press, Oxford, 1976.
Bjorklund, reprint J. Nat. Cancer, Inst., vol. 26, Mar. 1961, pp. 533-545.
Bjorklund, reprint Analytical Biochem., vol. 41, May 1971, pp. 287-290.
Bjorklund, reprint The Retic Sys in Health & Dis:Immuno & Path. Aspects, 1976, Plenum Pub, N.Y., pp. 357-370.
Bjorklund, reprint Onco-Developmental Gene Expression, Acd. Press, N.Y., 1976, pp. 501-508.
AB Bonnierforetagen
Fagelson Anna P.
Hueschen Gordon W.
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