Cancer associated plexin B1 mutations

Details Cancer associated plexin B1 mutations Cancer associated plexin B1 mutations

2011-02-15

2011-02-15

Reddig, Peter J (Department: 1642)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S007210, C435S007230, C536S023100, C536S023500

Reexamination Certificate

active

07888007

ABSTRACT:
The present inventors have identified cancer associated mutations in plexinB1, which is a transmembrane receptor that mediates semaphorin signaling. The frequency of plexinB1 mutations, in particular in prostate and breast cancer, indicates that plexinB1 may be useful in the screening and diagnosis of cancer and as a drug target in the development of anti-cancer therapeutics.

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