Cancer associated gene protein expressed therefrom and uses ther

Details Cancer associated gene protein expressed therefrom and uses ther Cancer associated gene protein expressed therefrom and uses ther

1994-12-30

1998-12-01

LeGuyader, John L.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

435 6, 435183, 4353201, 435325, 536 231, 536 232, 536 235, C12N 1500, C12N 1585, C27H 7102

Patent

active

058437371

ABSTRACT:
We have now discovered that eukaryotes, including mammals, have a gene that encodes a multifunctional protein having helicase activity, DNA repair activity, p53 sequestering activity and oncogenetic transformation potential. Enhanced transcripts and expression of this gene in non-testicular cells have a high correlation to disease state in a number of cancers, such as colorectal carcinomas, hereditary cancers resulting from defects in DNA repair pathways, breast cancers, etc. Accordingly, discovering enhanced levels of transcript or gene product in non-testicular tissues can be diagnostic of a predisposition to cancer, and prognostic for a particular cancer.

REFERENCES:
patent: 5585479 (1996-12-01), Hoke et al.
Gewirtz et al., Facilitating oligonucleotide delivery: Helping antisense deliver on its promise, Proc. Natl. Acad. Sci., vol. 93, pp. 3161-3163, Apr. 1996.
Orkin et al., Report and recomendations of the panel to assess the NIH investment in research on gene therapy, pp. 1-41, Dec. 7, 1995.
Ngo et al., Computational complexity, protein structure prediction, and the Levinthal paradox, The Protein Folding Problem and Tertiary Structure Prediction, pp. 434-440, 1994.
Pawlak A, et al., EMBL Database entry HS3078 (abstract).
Pawlak A, et al., Genomics vol. 26, pp. 151-158 (1995).
Lemaire L, et al., Life Sci 52(11) pp. 917-926 (1993).
Leroy P, et al., Cell 57 (4), pp.549-559 (1989).
Kerr SM, et al., Mammalian Genome 5(9), pp. 557-565 (1994).
Gee SL, et al., Gene (Amsterdam) 14(2), pp. 171-177 (1994).

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