Cancer antigen peptides derived from WT1

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...

Reexamination Certificate

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C424S277100, C514S015800, C530S328000

Reexamination Certificate

active

07622119

ABSTRACT:
The present invention relates to HLA-A26-binding cancer antigen peptides derived from WT1, polynucleotides encoding such a peptide, CTL-inducers, and cancer vaccines comprising such a peptide or polynucleotide.

REFERENCES:
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patent: 2003/0082194 (2003-05-01), Gaiger et al.
patent: 2002 525099 (2002-08-01), None
patent: 00 26249 (2000-05-01), None
patent: WO 01/25273 (2001-04-01), None
patent: WO 03/037060 (2003-05-01), None
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Liquan, G. et al., Selective Elimination of Leukemic CD34+Progenitor Cells by Cytotoxic T Lymphocytes Specific for WT1, Blood, vol. 95, No. 7, pp. 2198-2203, 2000.
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Akihiro Tsuboi, et al., “Enhanced Induction of Human WT1-Specific Cytotoxic T Lymphocytes With a 9-Mer WT1 Peptide Modified at HLA-A*2402-Binding Residues”, Cancer Immunology and Immunotherapy, XP 002961732, vol. 51, No. 11-12, Dec. 2002, 6 Pages.
Alexander Gaiger, et al., “Immunity to WT1 in the Animal Model and in Patients With Acute Myeloid Leukemia”, Blood, XP 002965863, vol. 96, No. 4, Aug. 15, 2000, pp. 1480-1489.
Hideki Ohminami, et al., “HLA Class I-Restricted Lysis of Leukemia Cells by a CD8+Cytotoxic T-Lymphocyte Clone Specific for WT1 Peptide”, Blood, XP 002190642, vol. 95, No. 1 Jan. 1, 2000, pp. 286-293.
J. Konya, et al. “Identification of a cytotoxic T-lymphocyte epitope in the human papillomavirus type 16 E2 protein”, Journal of General Virology, vol. 78, pp, 2615-2620 (1997).

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