Camptothecin derivatives

Details Camptothecin derivatives Camptothecin derivatives

1996-12-27

1999-04-06

Tsang, Cecilia J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514279, 514283, 514 2, 514 18, 514 19, 530333, 530322, C07D47100

Patent

active

058920439

ABSTRACT:
##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are (A) adjacent two groups combine to form alkylene, or both are H, and one of the remaining three groups is --X.sub.n --Alk.sub.m --R.sup.6, and the other two are H, alkyl or halogen, or (B) adjacent two groups combine to form alkylene, and one of the carbon atoms of said alkylene group is substituted by --X.sub.n --Alk.sub.m --R.sup.6, and the remaining three groups are H, alkyl or a halogen, and one or two --CH.sub.2 -- of the alkylene in (A) or (B) may optionally be replaced by --O--, --S-- or --NH--, X is --O-- or --NH--, Alk is alkylene, R.sup.6 is --NH.sub.2, ##STR2## or --OH, m and n are both 0 or 1, or m is 1 and n is 0, which camptothecin compound is bound to a polysaccharide having carboxyl groups via an amino acid or a peptide, or a pharmaceutically acceptable salt thereof. Said camptothecin derivatives show enhanced antitumor activities but few side effects and are useful as a medicament.

REFERENCES:
Abstract of Japanese document 1-279891, Abstract No. 89-001081/01 (Nov. 10, 1989).
Abstract of Japanese document 5-222048, Abstract No. 93-145471/18 (Aug. 31, 1993).
Abstract of Japanese document 6-87746, Abstract No. 94-140950/17 (Mar. 29, 1994).
Abstract of Japanese document 6-228141, Abstract No. 93-265987/34 (Aug. 16, 1994).
Abstract of Japanese document 4-503505, Abstract No. 90-132098/17 (Apr. 15, 1993).
Abstact of Japanes document5-502017, Abstract No. 91-117470/16 (Jun. 25, 1992).
Zhang et al., Chemical Abstracts, vol. 110, No. 12, 20 Mar. 1989, p. 413, Col. 2, Abstract No. 101605w.
Dr. Hisashi Furue, Cancer and Chemotherapy, (1994), vol. 21, p. 709, (brief comments thereon).
Science Forum Ltd., Enhancement of Effects of Anticancer Agents and Targeting Therapy, (1987), p. 227, (brief comments thereon).
Science Forum Ltd., Enhancement fo Effects of Anticancer Agents and Targeting Therapy, (1987), p. 278, (brief comments thereon).

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