1996-07-30
1998-11-17
Tsang, Cecilia J.
Tools
514 18, 514 19, 530322, 530330, 530331, 544346, 544361, A61K 3100, A61K 3814, C07K 900
Patent
active
058376739
ABSTRACT:
##STR1## wherein R.sup.1 is a substituted or unsubstituted lower alkyl group, X.sup.1 is a group of the formula: --NHR.sup.2 (R.sup.2 is a hydrogen atom or a lower alkyl group) or a group of --OH, and Alk is a straight chain or branched chain alkylene group having optionally an oxygen atom in the chain thereof, bound to a polysaccharide having carboxyl groups via an amino acid or a peptide, or a pharmaceutically acceptable salt thereof. Said camptothecin derivatives show enhanced antitumor activities but few side effects unlike conventional anticancer agents, and hence, these compounds are extremely useful as a medicament.
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Kawaguchi Takayuki
Okuno Satoshi
Tsujihara Kenji
Yano Toshiro
Culsa Bennett
Tanabe Seiyaku Co. Ltd.
Tsang Cecilia J.
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