Camptothecin compounds with combined topoisomerase I inhibition

Details Camptothecin compounds with combined topoisomerase I inhibition Camptothecin compounds with combined topoisomerase I inhibition

1997-10-08

1999-08-03

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 71, A61K 31395, C07D491147

Patent

active

059325887

ABSTRACT:
Camptothecin compounds having a --CH.sub.2 --L group are effective anti-tumor compounds. These compounds inhibit the enzyme topoisomerase I and DNA of associated topoisomerase I-DNA complexes.

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