Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1990-12-31
1992-06-16
Rivers, Diana G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514283, 544361, 546 41, 546 48, A61K 3147, C07D49122, C07D491147
Patent
active
051225263
ABSTRACT:
A method for synthesizing camptothecin and camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin analogs are effective inhibitors of topoisomerase I and show anti-leukemic and anit-tumor activity.
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Manikumar Govindarajan
Nicholas Allan W.
Wall Monroe E.
Wani Mansukh C.
Research Triangle Institute
Rivers Diana G.
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