Camptothecin analogs having an E-ring ketone

Details Camptothecin analogs having an E-ring ketone Camptothecin analogs having an E-ring ketone

2006-07-04

2006-07-04

Desai, Rita (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S058000

Reexamination Certificate

active

07071204

ABSTRACT:
Camptothecin analogs having an E-ring ketone are effective anti tumor compounds. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I DNA cleavable complex.

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International Search Report/PCTUS04/17436, (International filing date, Jun. 30, 2004).
Written Opinion of the International Searching Authority/PCT/US04/17436.

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