Camptothecin analogs as potent inhibitors of topoisomerase I

Details Camptothecin analogs as potent inhibitors of topoisomerase I Camptothecin analogs as potent inhibitors of topoisomerase I

1989-10-23

1992-04-21

Page, Thurman K.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Isomerase

435183, 435184, 514283, C12N 900, C12N 990, C12N 999, A61K 3144

Patent

active

051067420

ABSTRACT:
A method for synthesizing camptothecin and camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin analogs are effective inhibitors of topoisomerase I and show anti-leukemic and anti-tumor activity.

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