Camptothecin analogs and methods of preparation thereof

Details Camptothecin analogs and methods of preparation thereof Camptothecin analogs and methods of preparation thereof

2007-09-18

2007-09-18

Berch, Mark L. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Silicon containing doai

Reexamination Certificate

active

10629432

ABSTRACT:
The present invention provides generally a compound having the following general formula (1):wherein R1and R2are independently the same or different and are hydrogen, an alkyl group, an alkenyl group, a benzyl group, an alkynyl group, an alkoxyl group, an aryloxy group, an acyloxy group, a carbonyloxy group, a carbamoyloxy group, a halogen, a hydroxyl group, a nitro group, a cyano group, an azido group, a formyl group, a hydrazino group, an acyl group, an amino group, —SRc, wherein, Rcis hydrogen, an acyl group, an alkyl group, or an aryl group, or R1and R2together form a group of the formula —O(CH2)nO— wherein n represents the integer 1 or 2; R3is H, F, a halogen atom, a nitro group, an amino group, a hydroxyl group, or a cyano group; or R2and R3together form a group of the formula —O(CH2)nO— wherein n represents the integer 1 or 2; R4is H, F, a C1-3alkyl group, a C2-3alkenyl group, a C2-3alkynyl group, or a C1-3alkoxyl group; R5is a C1-10alkyl group, or a propargyl group; and R6, R7and R8are independently a C1-10alkyl group, a C2-10alkenyl group, a C2-10alkynyl group, an aryl group or a —(CH2)NR9group, wherein N is an integer within the range of 1 through 10 and R9is a hydroxyl group, alkoxy group, an amino group, an alkylamino group, a dialkylamino group, a halogen atom, a cyano group or a nitro group; and pharmaceutically acceptable salts thereof.

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